N,N'-Dimethyl-N,N'-bis-(3-amino-propyl)-trimethylendiamin | 999-41-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-Dimethyl-N,N'-bis-(3-amino-propyl)-trimethylendiamin
• 英文别名: N1,N3-Bis(3-aminopropyl)-N1,N3-dimethyl-1,3-propanediamine；N'-[3-[3-aminopropyl(methyl)amino]propyl]-N'-methylpropane-1,3-diamine
• CAS: 999-41-7
• 化学式: C₁₁H₂₈N₄
• 分子量: 216.37
• InChiKey: OATGBXQXGBCIES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N,N'-Dimethyl-N,N'-bis-<2-cyanethyl>-trimethylendiamin 在 镍 氢气 作用下， 以 甲醇 、 氨 为溶剂， 生成 N,N'-Dimethyl-N,N'-bis-(3-amino-propyl)-trimethylendiamin
  参考文献：
  名称：

  �ber Bis-trimethoxy-benzamide,-phenylharnstoffe,-phenylurethane und verwandte Derivate von Dialkyl-�thylendiaminen und-piperazinen

  摘要：

  DOI：

  10.1007/bf00908806

文献信息

• POLYAMINES USEFUL AS ANTI-PARASITIC AND ANTI-CANCER THERAPEUTICS AND AS LYSINE-SPECIFIC DEMETHYLASE INHIBITORS
  申请人：Woster M. Patrick

  公开号：US20070208082A1

  公开（公告）日：2007-09-06

  Polyamine, polyamine/guanidino, and polyamine/biguanide compounds are disclosed. The compounds are useful as anti-cancer and anti-parasitic treatments. The compounds are also useful as inhibitors of the enzyme lysine-specific demethylase-1.
• FLOWCELL SYSTEMS FOR SINGLE MOLECULE DETECTION
  申请人：Williams John G.K.

  公开号：US20110039266A1

  公开（公告）日：2011-02-17

  The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection channel. By electrically sorting charged molecules, the cleaved product molecules are detected in isolation without interference from unincorporated NPs and without illuminating the polymerase-DNA complex.
• LYSINE-SPECIFIC DEMETHYLASE INHIBITORS
  申请人：Woster Patrick M.

  公开号：US20110092601A1

  公开（公告）日：2011-04-21

  Polyamine, polyamine/guanidino, and polyamine/biguanide compounds bearing allene, propargyl, cyclopropyl, and other reactive moieties are disclosed. The compounds are useful as irreversible inhibitors of the enzyme lysine-specific demethylase-1 and for the treatment of cancer.
• US4647409A
  申请人：——

  公开号：US4647409A

  公开（公告）日：1987-03-03
• US8148577B2
  申请人：——

  公开号：US8148577B2

  公开（公告）日：2012-04-03