6-(对甲苯胺基)-2-萘磺酸钠 | 53313-85-2

• 物质功能分类: 化学试剂 - 有机试剂 - 磺酸盐/亚磺酸盐
• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 6-(对甲苯胺基)-2-萘磺酸钠
• 英文名称: 2,6-p-toluidinonaphthalene sulfonate sodium salt
• 英文别名: sodium 6-(p-toluidino)-2-naphthalenesulfonate；2-(p-Toluidino)naphthalene-6-sulfonic acid sodium salt；sodium;6-(4-methylanilino)naphthalene-2-sulfonate
• CAS: 53313-85-2
• 化学式: C₁₇H₁₄NO₃S*Na
• 分子量: 335.359
• InChiKey: QZZGQOXRGFDEJP-UHFFFAOYSA-M

物化性质

• 熔点：
  >300°C (dec.)
• 溶解度：
  可溶于DMSO（轻微）、甲醇（轻微、加热）

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  77.6
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38,R38
• WGK Germany：
  3

制备方法与用途

用途 

适于用作荧光探针

反应信息

• 作为反应物：
  描述：

  (1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R)-5,10,15,20,30,35-hexakis(hydroxymethyl)-25-[2-[2-[2-[[(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R)-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecahydroxy-5,15,20,25,30,35-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontan-10-yl]methoxy]ethoxy]ethoxy]ethoxymethyl]-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecol 、 6-(对甲苯胺基)-2-萘磺酸钠 生成
  参考文献：
  名称：

  新型双乙二醇连接双（β-环糊精）的合成及其与有机染料的包合作用

  摘要：

  Three novel bis(β‐cyclodextrin (CD))s with flexible glycol linkers, i.e., ethylene glycol‐bridged bis(6‐hydroxy‐6‐deoxy‐β‐CD) (2), diethylene glycol‐bridged bis(6‐hydroxy‐6‐deoxy‐β‐CD) (3), and triethylene glycol‐bridged bis(6‐hydroxy‐6‐deoxy‐β‐CD) (4) have been synthesized by the reaction of mono[6‐O‐(p‐toluenesulfonyl)]‐β‐CD with corresponding materials. The inclusion complexation behaviors of these

  DOI：

  10.1002/hlca.200900345

文献信息

• IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
  申请人：Arcturus Therapeutics, Inc.

  公开号：US20180170866A1

  公开（公告）日：2018-06-21

  What is described is a compound of formula I consisting of a compound in which R 1 is a branched chain alkyl consisting of 10 to 31 carbons; R 2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons, or a branched chain alkyl consisting of 10 to 31 carbons; L 1 and L 2 are the same or different, each a linear alkane of 1 to 20 carbons or a linear alkene of 2 to 20 carbons; X 1 is S or O; R 3 is a linear or branched alkylene consisting of 1 to 6 carbons; and R 4 and R 5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.

  描述的是一种化合物，其化学式为I，包括以下成分： R1为由10至31个碳组成的支链烷基； R2为由2至20个碳组成的直链烷基、烯烃或炔烃，或者由10至31个碳组成的支链烷基； L1和L2相同或不同，每个为由1至20个碳组成的直链烷烃或由2至20个碳组成的直链烯烃； X1为S或O； R3为由1至6个碳组成的直链或支链烷基；以及 R4和R5相同或不同，每个为氢或由1至6个碳组成的直链或支链烷基；或其药用可接受盐。
• CATIONIC LIPID FOR NUCLEIC ACID DELIVERY
  申请人：NOF Corporation

  公开号：EP3184506A1

  公开（公告）日：2017-06-28

  An object of the present invention is to provide a cationic lipid capable of achieving higher intracellular delivery efficiency than conventional cationic lipids, when used as a lipid membrane structure which is a carrier for delivering functional nucleic acid. A cationic lipid represented by the formula (1): wherein each symbol is as defined in the present DESCRIPTION.

  本发明的目的是提供一种阳离子脂质，当其用作输送功能性核酸的载体的脂膜结构时，能够获得比传统阳离子脂质更高的细胞内输送效率。 由式（1）代表的阳离子脂质： 其中各符号如本说明书所定义。
• RADIATION DOSIMETRY SOL OR GEL AND RADIATION DOSIMETER COMPRISING SAME AS MATERIAL FOR RADIATION DOSIMETRY
  申请人：Riken

  公开号：EP3686632A1

  公开（公告）日：2020-07-29

  There is provided a radiation dosimetry sol or gel, and a radiation dosimeter containing the sol or the gel as a material for radiation dosimetry. A radiation dosimetry sol or gel characterized by comprising a compound (A) having an excitation light-induced fluorescence property that is changed by a radiolysis product of water; and a silicate salt (B). A radiation dosimetry sol or gel characterized by comprising a compound (A) having an excitation light-induced fluorescence property that is changed by a radiolysis product of water; a silicate salt (B); a water-soluble organic polymer (C) having an organic acid salt structure or an organic acid anion structure; and a dispersant (D) for the silicate salt (B). A radiation dosimeter comprising, as a material for radiation dosimetry, the above-mentioned radiation dosimetry sol or gel.

  提供了一种辐射剂量测定溶胶或凝胶，以及一种含有该溶胶或凝胶作为辐射剂量测定材料的辐射剂量计。 一种辐射剂量测定溶胶或凝胶，其特征在于包含一种化合物 (A)，该化合物具有由水的辐射分解产物改变的激发光诱导荧光特性；以及一种硅酸盐 (B)。 一种辐射剂量计溶胶或凝胶，其特征在于包含一种化合物（A），该化合物具有受水的辐射分解产物影响而改变的激发光诱导荧光特性；一种硅酸盐（B）；一种具有有机酸盐结构或有机酸阴离子结构的水溶性有机聚合物（C）；以及一种用于硅酸盐（B）的分散剂（D）。 一种辐射剂量计，包括作为辐射剂量测定材料的上述辐射剂量测定溶胶或凝胶。
• Cationic lipid for nucleic acid delivery
  申请人：NOF CORPORATION

  公开号：US10092655B2

  公开（公告）日：2018-10-09

  The invention provides a cationic lipid capable of achieving higher intracellular delivery efficiency than conventional cationic lipids, when used as a lipid membrane structure which is a carrier for delivering functional nucleic acid. The cationic lipid is represented by the formula (1): wherein each symbol is as defined herein.

  本发明提供了一种阳离子脂质，当用作输送功能性核酸的载体的脂膜结构时，能够获得比传统阳离子脂质更高的细胞内输送效率。该阳离子脂质由式（1）表示： 其中各符号如本文所定义。
• Tandem folding methods to improve protein folding yield
  申请人：Purdue Research Foundation

  公开号：US10633414B2

  公开（公告）日：2020-04-28

  Methods of refolding proteins are provided, especially cysteine-containing proteins such as insulin, proinsulin, and analogues thereof. The methods make used of tandem folding via the addition, at two different time, of two different reducing agents. A first reversible reducing agent can be added to induce folding and, at a later time, a second irreversible reducing agent can be added to prevent and/or reverse the formation of aggregates via intermolecular sulfide bonds. The methods can be used to reform a variety of cysteine-containing proteins with high yield of the native form, e.g. about 60 mol %, 70 mol %, or more.

  本研究提供了重折叠蛋白质的方法，特别是含半胱氨酸的蛋白质，如胰岛素、原胰岛素及其类似物。这些方法通过在两个不同的时间添加两种不同的还原剂来实现串联折叠。可以添加第一种可逆还原剂来诱导折叠，之后再添加第二种不可逆还原剂来防止和/或逆转通过分子间硫化键形成的聚集体。这些方法可用于改造各种含半胱氨酸的蛋白质，并获得高产率的原生形式，例如约 60 摩尔%、70 摩尔% 或更高。