1-(6-morpholinopyridin-3-yl)-3-phenylpropanone | 259260-15-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(6-morpholinopyridin-3-yl)-3-phenylpropanone
• 英文别名: 1-(6-Morpholin-4-ylpyridin-3-yl)-3-phenylpropan-1-one
• CAS: 259260-15-6
• 化学式: C₁₈H₂₀N₂O₂
• 分子量: 296.369
• InChiKey: BXYDDFJYZQKQJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(6-morpholinopyridin-3-yl)-3-phenylpropanone 在 ammonium acetate 作用下， 以 二乙二醇二甲醚 、 正丁醇 为溶剂， 反应 16.0h， 生成 6-Benzyl-5-(3-bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine
  参考文献：
  名称：

  5,6,7-Trisubstituted 4-Aminopyrido[2,3-d]pyrimidines as Novel Inhibitors of Adenosine Kinase

  摘要：

  The synthesis and structure-activity relationship of a series of 5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel nonnucleoside adenosine kinase inhibitors is described. A variety of alkyl, aryl, and heteroaryl substituents were found to be tolerated at the C5, C6, and C7 positions of the pyridopyrimidine core. These studies have led to the identification of analogues that are potent inhibitors of adenosine kinase with in vivo analgesic activity.

  DOI：

  10.1021/jm030327l
• 作为产物：
  描述：

  6-氯-n-甲氧基-n-甲基烟酰胺 以 四氢呋喃 、 乙醇 为溶剂， 反应 21.0h， 生成 1-(6-morpholinopyridin-3-yl)-3-phenylpropanone
  参考文献：
  名称：

  5,6,7-Trisubstituted 4-Aminopyrido[2,3-d]pyrimidines as Novel Inhibitors of Adenosine Kinase

  摘要：

  The synthesis and structure-activity relationship of a series of 5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel nonnucleoside adenosine kinase inhibitors is described. A variety of alkyl, aryl, and heteroaryl substituents were found to be tolerated at the C5, C6, and C7 positions of the pyridopyrimidine core. These studies have led to the identification of analogues that are potent inhibitors of adenosine kinase with in vivo analgesic activity.

  DOI：

  10.1021/jm030327l

文献信息

• Reductive Arylation of Amides via a Nickel‐Catalyzed Suzuki–Miyaura‐Coupling and Transfer‐Hydrogenation Cascade
  作者：Timothy B. Boit、Milauni M. Mehta、Junyong Kim、Emma L. Baker、Neil K. Garg

  DOI：10.1002/anie.202012048

  日期：2021.2

  method takes advantage of non‐precious‐metal catalysis and allows for the facile conversion of amides to chiral alcohols via a one‐pot Suzuki–Miyaura cross‐coupling/transfer‐hydrogenation process. This study is anticipated to promote the development of new transformations that allow for the conversion of carboxylic acid derivatives to functional groups bearing stereogenic centers via cascade processes

  我们报告了一种在单个操作步骤中将两种不同的亲核试剂加成到酰胺羰基碳上的方法。我们的方法利用非贵金属催化，并允许通过一锅铃木-宫浦交叉偶联/转移氢化过程将酰胺轻松转化为手性醇。这项研究预计将促进新转化的发展，使羧酸衍生物通过级联过程转化为带有立体中心的官能团。
• 5,6,7-Trisubstituted 4-Aminopyrido[2,3-<i>d</i>]pyrimidines as Novel Inhibitors of Adenosine Kinase
  作者：Richard J. Perner、Yu-Gui Gu、Chih-Hung Lee、Erol K. Bayburt、Jeffery McKie、Karen M. Alexander、Kathy L. Kohlhaas、Carol T. Wismer、Joe Mikusa、Michael F. Jarvis、Elizabeth A. Kowaluk、Shripad S. Bhagwat

  DOI：10.1021/jm030327l

  日期：2003.11.1

  The synthesis and structure-activity relationship of a series of 5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel nonnucleoside adenosine kinase inhibitors is described. A variety of alkyl, aryl, and heteroaryl substituents were found to be tolerated at the C5, C6, and C7 positions of the pyridopyrimidine core. These studies have led to the identification of analogues that are potent inhibitors of adenosine kinase with in vivo analgesic activity.