9-chloro-6-[2-(piperidin-1-yl)ethyl]-4-azachromeno[2,3-b]indol-11(6H)-one | 1214260-95-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃吡啶类
• 英文名称: 9-chloro-6-[2-(piperidin-1-yl)ethyl]-4-azachromeno[2,3-b]indol-11(6H)-one
• 英文别名: 13-Chloro-17-(2-piperidin-1-ylethyl)-2-oxa-4,17-diazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),3(8),4,6,11(16),12,14-heptaen-9-one；13-chloro-17-(2-piperidin-1-ylethyl)-2-oxa-4,17-diazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),3(8),4,6,11(16),12,14-heptaen-9-one
• CAS: 1214260-95-3
• 化学式: C₂₁H₂₀ClN₃O₂
• 分子量: 381.862
• InChiKey: HVDFNFSKZONTGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  47.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  9-chloro-4-azachromeno[2,3-b]indol-11(6H)-one 、 1-(2-氯乙基)哌啶盐酸盐 在 potassium carbonate 、 sodium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 以31.5%的产率得到9-chloro-6-[2-(piperidin-1-yl)ethyl]-4-azachromeno[2,3-b]indol-11(6H)-one
  参考文献：
  名称：

  Synthesis of 4-Azachromeno[2,3-b]indol-11(6H)-one and Its Derivatives as Analogues of Ellipticine

  摘要：

  4-Azachromeno[2,3-b]indol-11(6H)-ones (4) and their derivatives (5) as analogues of ellipticine were synthesized through a straightforward, two or three-step process. Tetracyclic heterocycles (4) were obtained by facile cyclization of indolin-2-ones (2) or (3) and 2-chloronicotinoyl chloride under the condition of the 'Jensen'-reaction. Alkylation of the compounds (4) afforded 6-substituted 4-azachromeno[2,3-b]indol-11(6H)-ones.

  DOI：

  10.3987/com-08-s(s)3

文献信息

• Synthesis of 4-Azachromeno[2,3-b]indol-11(6H)-one and Its Derivatives as Analogues of Ellipticine
  作者：Chunhao Yang、Yuyuan Xie、Yanhong Chen

  DOI：10.3987/com-08-s(s)3

  日期：——

  4-Azachromeno[2,3-b]indol-11(6H)-ones (4) and their derivatives (5) as analogues of ellipticine were synthesized through a straightforward, two or three-step process. Tetracyclic heterocycles (4) were obtained by facile cyclization of indolin-2-ones (2) or (3) and 2-chloronicotinoyl chloride under the condition of the 'Jensen'-reaction. Alkylation of the compounds (4) afforded 6-substituted 4-azachromeno[2,3-b]indol-11(6H)-ones.