7-[(phenylsulfanyl)methyl]-7,8-dihydro[1,3]thiazolo[2,3-i]purine | 1424011-94-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 7-[(phenylsulfanyl)methyl]-7,8-dihydro[1,3]thiazolo[2,3-i]purine
• CAS: 1424011-94-8
• 化学式: C₁₄H₁₂N₄S₂
• 分子量: 300.408
• InChiKey: YLTVFOGEPUTGOB-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  7-[(phenylsulfanyl)methyl]-7,8-dihydro[1,3]-thiazolo[2,3-i]purin-6-ium perchlorate 在 sodium acetate 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以91%的产率得到7-[(phenylsulfanyl)methyl]-7,8-dihydro[1,3]thiazolo[2,3-i]purine
  参考文献：
  名称：

  Synthesis of 7-iodo(arylsulfanyl)methyl-7,8-dihydro-[1,3]thiazolo[2,3-i]purinium pentaiodide (perchlorates) and their transformation into 4-amino-5-(1,3-thiazol-2-yl)imidazole derivatives

  摘要：

  Intramolecular electrophilic cyclization of 6-allylsulfanylpurine by the action of iodine and arenesulfenyl chlorides gave 7-iodomethyl-7,8-dihydro[1,3]thiazolo[2,3-i]purin-6-ium pentaiodide and 7-arylsulfanylmethyl-7,8-dihydro[1,3]thiazolo[2,3-i]purin-6-ium perchlorates, respectively. 7-Iodomethyl-7,8-dihydro-[1,3]thiazolo[2,3-i]purin-6-ium iodide reacted with sodium and potassium alkoxides to produce alkyl N-[5-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-4-yl]formimidates, and its reaction with secondary cyclic amines afforded 5-(4-methyl-1,3-thiazol-2-yl)-N-[morpholin-4-yl(or piperidin-1-yl)methylidene]-1H-imidazol-4-amines. Successive treatment of 7-arylsulfanylmethyl-7,8-dihydro[1,3]thiazolo[2,3-i]purin-6-ium perchlorates with sodium acetate and morpholine led to the formation of 5-(4-arylsulfanylmethyl-4,5-dihydro-1,3-thiazol-2-yl)-N-(morpholin-4-ylmethylidene)-1H-imidazol-4-amines. DOI: 10.1134/S1070428013010211

  DOI：

  10.1134/s1070428013010211