4-(5-chloro-2-hydroxy benzylidene amino)-pyridine | 15877-15-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(5-chloro-2-hydroxy benzylidene amino)-pyridine
• 英文别名: 4-Chloro-2-(pyridin-4-yliminomethyl)phenol
• CAS: 15877-15-3
• 化学式: C₁₂H₉ClN₂O
• 分子量: 232.669
• InChiKey: GYJSEBXNWKCRLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氨基吡啶 、 5-氯代水杨醛 以 乙醇 为溶剂， 反应 4.0h， 生成 4-(5-chloro-2-hydroxy benzylidene amino)-pyridine
  参考文献：
  名称：

  Synthesis, characterization, and antifungal activity of novel quaternary chitosan derivatives

  摘要：

  Three novel quaternary chitosan derivatives were successfully synthesized by reaction of chloracetyl chitosan (CACS) with pyridine (PACS), 4-(5-chloro-2-hydroxybenzylideneamino)-pyridine (CHPACS), and 4-(5-bromo-2-hydroxybenzylideneamino)-pyridine (BHPACS). The chemical structure of the prepared chitosan derivatives was confirmed by Fourier transform infrared (FT-IR) and C-13 nuclear magnetic resonance (C-13 NMR) and their antifungal activity against Cladosporium cucumerinum, Monilinia fructicola, Colletotrichum lagenarium, and Fusarium oxysporum was assessed. Comparing with the antifungal activity of chitosan, CACS, and PACS, CHPACS and BHPACS exhibited obviously better inhibitory effects, which should be related to the synergistic reaction of chitosan itself with the grafted 2-[4-(5-chloro-2-hydroxybenzylideneamino)-pyridyl]acetyl and 2[4-(5-bromo-2-hydroxybenzylideneamino)-pyridyl]acetyl. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2010.05.029