9α,17β-dihydroxy-5α-androstan-3-one | 55541-95-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 9α,17β-dihydroxy-5α-androstan-3-one
• 英文别名: 9a,17b-Dihydroxy-5a-androstane-3-one；(5S,8S,9R,10S,13S,14S,17S)-9,17-dihydroxy-10,13-dimethyl-2,4,5,6,7,8,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
• CAS: 55541-95-2
• 化学式: C₁₉H₃₀O₃
• 分子量: 306.445
• InChiKey: PFKKLLXEXNNDNF-GLOHGQAKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  雄诺龙 以 乙醇 为溶剂， 反应 48.0h， 以16.6%的产率得到7-羟基二氢睾酮
  参考文献：
  名称：

  Crabb, Trevor A.; Ratcliffe, Norman M., Journal of Chemical Research, Miniprint, 1986, # 2, p. 650 - 669

  摘要：

  DOI：

文献信息

• FORMULATIONS OF DEOXYCHOLIC ACID AND SALTS THEREOF
  申请人：Hodge Robert Emil

  公开号：US20120258943A1

  公开（公告）日：2012-10-11

  The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.

  本申请涉及一种水性药物组合物，包括约0.4％w/v至少于约2％w/v的去氧胆酸盐，并且该组合物的pH值保持在约8.1至约8.5之间，以使该组合物稳定不沉淀。本文还公开了一种稳定水性药物组合物的方法，该组合物包括约0.4％w/v至少于约2％w/v的去氧胆酸盐，并且该方法包括将溶液的pH值保持在约8.1至约8.5之间。
• Formulations of Deoxycholic Acid and Salts Thereof
  申请人：Kythera Biopharmaceuticals, Inc.

  公开号：EP2561876A1

  公开（公告）日：2013-02-27

  The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.

  本申请涉及一种水性药物组合物，该组合物包含约 0.4% w/v 至小于约 2% w/v 的去氧胆酸盐，其中该组合物的 pH 值保持在约 8.1 至约 8.5 之间，从而稳定该组合物以防止沉淀。本文还公开了稳定包含约 0.4% w/v 至小于约 2% w/v 的脱氧胆酸盐的水性药物组合物以防止沉淀的方法，所述方法包括将溶液的 pH 值保持在约 8.1 至约 8.5 之间。
• Formulations of deoxycholic acid and salts thereof
  申请人：Kythera Biopharmaceuticals, Inc.

  公开号：EP2735310A1

  公开（公告）日：2014-05-28

  The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.

  本申请涉及一种水性药物组合物，该组合物包含约 0.4% w/v 至小于约 2% w/v 的去氧胆酸盐，其中该组合物的 pH 值保持在约 8.1 至约 8.5 之间，从而稳定该组合物以防止沉淀。本文还公开了稳定包含约 0.4% w/v 至小于约 2% w/v 的脱氧胆酸盐的水性药物组合物以防止沉淀的方法，所述方法包括将溶液的 pH 值保持在约 8.1 至约 8.5 之间。
• TREATMENTS OF ACCUMULATED FAT WITH DEOXYCHOLIC ACID AND SALTS THEREOF
  申请人：Kythera Biopharmaceuticals, Inc.

  公开号：US20170119794A1

  公开（公告）日：2017-05-04

  Provided herein are methods of treating a variety of disorders related to fat accumulation in humans with pharmaceutical formulations containing deoxycholic acid.
• US8653058B2
  申请人：——

  公开号：US8653058B2

  公开（公告）日：2014-02-18