5-hydroxy-2-[(imidazo[1,2-a]pyridin-2-ylmethyl)sulfanyl]-pyrimidin-4(3H)-one | 1417817-34-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 5-hydroxy-2-[(imidazo[1,2-a]pyridin-2-ylmethyl)sulfanyl]-pyrimidin-4(3H)-one
• 英文别名: 5-hydroxy-2-(imidazo[1,2-a]pyridin-2-ylmethylsulfanyl)-1H-pyrimidin-6-one
• CAS: 1417817-34-5
• 化学式: C₁₂H₁₀N₄O₂S
• 分子量: 274.303
• InChiKey: GACAWNMHZOLVKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• PYRIMIDINONE COMPOUNDS AND THEIR USE
  申请人：Cockcroft Xiao-Ling Fan

  公开号：US20140248378A1

  公开（公告）日：2014-09-04

  The present invention provides compounds of formula (1) and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , Y and Z are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明提供公式（1）的化合物及其药学上可接受的盐，其中R1，R2，Y和Z如规范中所定义，其制备过程，含有它们的制药组合物以及它们在治疗中的应用。
• Pyrimidinone compounds and their use
  申请人：Cockcroft Xiao-Ling Fan

  公开号：US10085986B2

  公开（公告）日：2018-10-02

  The present invention provides compounds of formula (1) and pharmaceutically acceptable salts thereof, wherein R1, R2, Y and Z are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明提供了式 (1) 化合物及其药学上可接受的盐（其中 R1、R2、Y 和 Z 如说明书中所定义）、其制备工艺、含有它们的药物组合物以及它们在治疗中的用途。
• [EN] PYRIMIDINONE COMPOUNDS AND THEIR USE<br/>[FR] COMPOSÉS PYRIMIDINONES ET LEUR UTILISATION
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2013004995A1

  公开（公告）日：2013-01-10

  The present invention provides compounds of formula (1) and pharmaceutically acceptable salts thereof, wherein R1, R2, Y and Z are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.