| 1260496-15-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• CAS: 1260496-15-8
• 化学式: C₇₂H₁₁₇N₃O₉
• 分子量: 1168.74
• InChiKey: GRABMCZASMPIKZ-ZBCPVNPBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.5
• 重原子数：
  84.0
• 可旋转键数：
  0.0
• 环数：
  25.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  208.68
• 氢给体数：
  9.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  在 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 1-羟基苯并三唑 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 以76%的产率得到
  参考文献：
  名称：

  Water-Templated Transmembrane Nanopores from Shape-Persistent Oligocholate Macrocycles

  摘要：

  Hydrophobic interactions normally are not considered a major driving force for self-assembling in a hydrophobic environment. When macrocyclic oligocholates were placed within lipid membranes, however, the macrocycles pulled water molecules from the aqueous phase into their hydrophilic internal cavities. These water molecules had strong tendencies to aggregate in a hydrophobic environment and templated the macrocycles to self-assemble into transmembrane nanopores. This counterintuitive hydrophobic effect resulted in some highly unusual transport behavior. Cholesterol normally increases the hydrophobicity of lipid membranes and makes them less permeable to hydrophilic molecules. The permeability of glucose across the oligocholate-containing membranes, however, increased significantly upon the inclusion of cholesterol. Large hydrophilic molecules tend to have difficulty traversing a hydrophobic barrier. The cyclic cholate tetramer, however, was more effective at permeating maltotriose than glucose.

  DOI：

  10.1021/ja109036z