| 710320-24-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• CAS: 710320-24-4
• 化学式: C₆₄H₁₁₁N₅O₁₄
• 分子量: 1174.61
• InChiKey: UPDDHTPDZRCIBZ-HAILBEPGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.1
• 重原子数：
  83.0
• 可旋转键数：
  26.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  235.46
• 氢给体数：
  4.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  在 三氟乙酸 作用下， 以 氯仿 为溶剂， 反应 0.75h， 以99%的产率得到
  参考文献：
  名称：

  New cationic lipids for gene transfer with high efficiency and low toxicity: T-shape cholesterol ester derivatives

  摘要：

  New degradable cationic ester lipids with 'T-shape' configurations were synthesized and tested for gene delivery carrier. Their transfection efficiency and toxicity were compared with commercially available cationic lipids, DOTMA, DOSPA, and DC-Chol. They showed efficient transfection activity and almost no toxicity on mammalian cell lines. Their ester bond degradation was monitored by H-1 NMR. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.02.061
• 作为产物：
  描述：

  胆固醇甲酰氯 在 4-二甲氨基吡啶 、 对甲苯磺酸 、 三乙胺 、 N,N'-二异丙基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  New cationic lipids for gene transfer with high efficiency and low toxicity: T-shape cholesterol ester derivatives

  摘要：

  New degradable cationic ester lipids with 'T-shape' configurations were synthesized and tested for gene delivery carrier. Their transfection efficiency and toxicity were compared with commercially available cationic lipids, DOTMA, DOSPA, and DC-Chol. They showed efficient transfection activity and almost no toxicity on mammalian cell lines. Their ester bond degradation was monitored by H-1 NMR. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.02.061