8-bromo-2-methylindolo[2,1-b]quinazoline-6,12-dione | 1443052-03-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 8-bromo-2-methylindolo[2,1-b]quinazoline-6,12-dione
• CAS: 1443052-03-6
• 化学式: C₁₆H₉BrN₂O₂
• 分子量: 341.164
• InChiKey: LEASGGOXPZLZRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  49.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-甲基靛红酸酐 、 5-溴靛红 在 cobalt(III) meso-5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin chloride 作用下， 以 乙醇 、 水 为溶剂， 反应 5.0h， 以90%的产率得到8-bromo-2-methylindolo[2,1-b]quinazoline-6,12-dione
  参考文献：
  名称：

  Cobalt(III)–porphyrin complex (CoTCPP) as an efficient and recyclable homogeneous catalyst for the synthesis of tryptanthrin in aqueous media

  摘要：

  The water soluble cobalt(III) porphyrin complex (CoTCPP) was employed as an efficient catalyst for the synthesis of the biologically active natural product tryptanthrin. The reaction proceeded under mild conditions in aqueous media at room temperature from various isatoic anhydride and isatin derivatives. The advantages of these reactions were excellent yields, short reaction times and a recoverable catalyst. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.12.052

文献信息

• Cu-Catalyzed Synthesis of Tryptanthrin Derivatives from Substituted Indoles
  作者：Chen Wang、Lianpeng Zhang、Anni Ren、Ping Lu、Yanguang Wang

  DOI：10.1021/ol401144m

  日期：2013.6.21

  A concise method for the preparation of tryptanthrins from indoles via the copper-catalyzed aerobic oxidation is described. The reactions can be carried out under mild reaction conditions with varying functional group tolerance.

  描述了一种通过铜催化的需氧氧化从吲哚制备色胺酮的简明方法。反应可以在温和的反应条件下以不同的官能团耐受性进行。
• Synthesis of Tryptanthrins by Organocatalytic and Substrate Co-catalyzed Photochemical Condensation of Indoles and Anthranilic Acids with Visible Light and O₂
  作者：Xiangmin Li、He Huang、Chenguang Yu、Yueteng Zhang、Hao Li、Wei Wang

  DOI：10.1021/acs.orglett.6b03009

  日期：2016.11.4

  A metal-free catalytic approach to tryptanthrins has been achieved for the first time. The unique process is realized by an organocatalytic and indole and anthranilic acid substrate co-catalyzed photochemical oxidative condensation with visible light and O2. The truly environmentally friendly reaction conditions enable various reactants to participate in the process to deliver structurally diverse

  首次实现了无金属的类胰色胺的催化方法。独特的工艺是通过有机催化剂与吲哚和邻氨基苯甲酸底物与可见光和O 2共同催化光化学氧化缩合而实现的。真正的环境友好型反应条件使各种反应物都能参与该过程，从而提供结构多样的色胺酮。