Ethyl-phthalimidomethyl-carbonat | 35180-00-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: Ethyl-phthalimidomethyl-carbonat
• 英文别名: N-ethoxycarbonyloxymethyl-phthalimide；(1,3-Dioxoisoindol-2-yl)methyl ethyl carbonate
• CAS: 35180-00-8
• 化学式: C₁₂H₁₁NO₅
• 分子量: 249.223
• InChiKey: RXIOHWKXYNOWLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Process for the preparation of ibrutinib
  申请人：SHILPA MEDICARE LIMITED

  公开号：US10435409B2

  公开（公告）日：2019-10-08

  The present invention relates to a process for the preparation of 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one or Ibrutinib of Formula (I). The present invention further relates to a process for the preparation highly pure 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one or Ibrutinib(I).

  本发明涉及一种制备1-[(3R)-3-[4-氨基-3-(4-苯氧基苯基)-1H-吡唑并[3,4-d]嘧啶-1-基]-1-哌啶基]-2-丙烯-1-酮或式(I)的伊布替尼的工艺。 本发明进一步涉及一种制备高纯度 1-[(3R)-3-[4-氨基-3-(4-苯氧基苯基)-1H-吡唑并[3,4-d]嘧啶-1-基]-1-哌啶基]-2-丙烯-1-酮或 Ibrutinib(I) 的工艺。
• PROCESS FOR THE PREPARATION OF IBRUTINIB
  申请人：SHILPA MEDICARE LIMITED

  公开号：US20190040069A1

  公开（公告）日：2019-02-07

  The present invention relates to a process for the preparation of 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one or Ibrutinib of Formula (I). The present invention further relates to a process for the preparation highly pure 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one or Ibrutinib(I)
• [EN] PROCESS FOR MODIFYING AN AROMATIC POLYETHER BACKBONE AND A MODIFIED POLYETHER OBTAINED BY THIS PROCESS<br/>[FR] PROCÉDÉ DE MODIFICATION D'UN SQUELETTE POLYÉTHER AROMATIQUE ET UN POLYÉTHER MODIFIÉ OBTENU PAR CE PROCÉDÉ
  申请人：[en]TECHNISCHE UNIVERSITÄT BERLIN

  公开号：WO2022167637A1

  公开（公告）日：2022-08-11

  The present invention relates to a process for modifying an aromatic polyether backbone for obtaining a modified polyether comprising the steps of: a) providing the at least one aromatic polyether to be modified in dissolved state in an inert organic solvent, b) adding at least one modification reagent, c) adding at least one catalyst, d) carrying out the process until a desired degree of functionalization of said aromatic polyether backbone is reached, e) recovery of the modified aromatic polyether. The present invention also relates to a modified polyether obtained by this process.