N-[2-[3',6'-bis(diethylamino)-3-sulfanylidenespiro[isoindole-1,9'-xanthene]-2-yl]ethyl]-4-methylbenzenesulfonamide | 1482506-02-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: N-[2-[3',6'-bis(diethylamino)-3-sulfanylidenespiro[isoindole-1,9'-xanthene]-2-yl]ethyl]-4-methylbenzenesulfonamide
• CAS: 1482506-02-4
• 化学式: C₃₇H₄₂N₄O₃S₂
• 分子量: 654.897
• InChiKey: NTJXHNWJHWSUNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  46
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  罗丹明B 在 三乙胺 、 肼 作用下， 以 乙醇 、 1,2-二氯乙烷 为溶剂， 生成 N-[2-[3',6'-bis(diethylamino)-3-sulfanylidenespiro[isoindole-1,9'-xanthene]-2-yl]ethyl]-4-methylbenzenesulfonamide
  参考文献：
  名称：

  A new sensitive and selective chromogenic and fluorescent chemodosimeter for Hg(Ⅱ) in aqueous media and its application in live cell imaging

  摘要：

  A new rhodamine-based chemodosimeter(L2) was synthesized and characterized, which contained a tosyl group acted as a strong electron acceptor. As expected, L2 exhibited high selectivity and excellent sensitivity in both absorbance and fluorescence detection of Hg2+ in aqueous solution. The coordination of L2 with Hg2+ was chemically nonreversible and it was based on the fact that Hg2+ exhibited a strong thiophilic affinity. Addition of Hg2+ to an ethanol aqueous solution of L2 resulted in a color change from color-less to obvious pink color, these significant changes in color could be used for naked-eye detection. Furthermore, fluorescence imaging experiments of Hg2+ ions in living MGC803 cells demonstrated its value of practical applications in biological systems. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2013.06.021