Quinuclidin-3-one oxime hydrochloride | 76883-37-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 英文名称: Quinuclidin-3-one oxime hydrochloride
• 英文别名: (NZ)-N-(1-azabicyclo[2.2.2]octan-3-ylidene)hydroxylamine;hydrochloride
• CAS: 76883-37-9
• 化学式: C7H13ClN2O
• 分子量: 176.64
• InChiKey: CSKIUBQPEHEMAN-USRGLUTNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.96
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  35.8
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

文献信息

• [EN] 1H-PYRAZOLE AND 1H-PYRROLE-AZABICYCLIC COMPOUNDS WITH ALFA-7 NACHR ACTIVITY<br/>[FR] COMPOSES AZABICYCLIQUE DE 1H-PYRAZOLE ET 1H-PYRROLE SERVANT A EFFECTUER UN TRAITEMENT THERAPEUTIQUE
  申请人：UPJOHN CO

  公开号：WO2004013137A1

  公开（公告）日：2004-02-12

  The invention provides compounds of Formula (I), wherein Azabicyclo is Formula (I, II, III, IV, V, VI, VII); W is Formula (m); where the variables have the definitions discussed herein. These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to treat a disease or condition in which α7 is known to be involved.

  这项发明提供了Formula (I)的化合物，其中Azabicyclo是Formula (I, II, III, IV, V, VI, VII); W是Formula (m); 其中变量的定义如本文所述。这些化合物可以是药用盐或组合物的形式，可以是纯对映体形式或混合物，对于治疗已知涉及α7的疾病或症状的药物具有用处。
• [EN] SUBSTITUTED AZABICYCLIC MOIETIES FOR THE TREATMENT OF DISEASE (NICOTINIC ACETHYLCHOLINE RECEPTOR ANTAGONISTS)<br/>[FR] FRACTIONS AZABICYCLIQUES SUBSTITUEES POUR LE TRAITEMENT DE MALADIES (ANTAGONISTES DU RECEPTEUR D'ACETHYLCHOLINE NICOTINIQUE)
  申请人：UPJOHN CO

  公开号：WO2002085901A1

  公开（公告）日：2002-10-31

  The invention provides compounds of Formula (I): (F) Formula (I) wherein m1 is 0 or 1; m2 is 1 or 2; R¿1? is-H, alkyl, halogenated alkyl, substituted alkyl, cycloakyl, or phenyl; R2 is -H, alkyl, halogenated alkyl, substituted alkyl, cycloalkyl, or phenyl, provided that when m?1¿ is 1 at least one of R¿1? and R2 is -H; or a pharmaceutically acceptable salt, pharmaceutical composition, a pure enantiomer or racemic mixture thereof. The invention also provides a method for treating a disease or condition in a mammal, wherein the ≡7 nicotinic acetylcholine receptor is implicated and for treating diseases where there is a sensory-gating deficit in a mammal comprising administering to a mammal a therapeutically effective amount of a compound of Formula (I). These compounds may be in the form of phamaceutical salts or compositions, and may be in pure enantiomeric form or may be racemic mixtures.

  本发明提供了式(I)的化合物：（F）式（I），其中m1为0或1；m2为1或2；R1为-H，烷基，卤代烷基，取代烷基，环烷基或苯基；R2为-H，烷基，卤代烷基，取代烷基，环烷基或苯基，但当m1为1时，R1和R2中至少有一个为-H；或其药学上可接受的盐，制药组合物，其纯对映体或外消旋混合物。本发明还提供了一种用于治疗哺乳动物中涉及到≡7尼古丁乙酰胆碱受体的疾病或状况的方法，并用于治疗哺乳动物中存在感觉门控缺陷的疾病，包括向哺乳动物施用式(I)化合物的治疗有效量。这些化合物可以是制药盐或组合物的形式，并且可以是纯对映体形式或外消旋混合物。
• [EN] QUINUCLIDINES-SUBSTITUTED-MULTI-CYCLIC-HETEROARYLS FOR THE TREATMENT OF DISEASE<br/>[FR] MULTI-HETEROARYLES CYCLIQUES SUBSTITUES PAR QUINUCLIDINES POUR LE TRAITEMENT DE MALADIES
  申请人：UPJOHN CO

  公开号：WO2002100857A1

  公开（公告）日：2002-12-19

  The invention provides compounds of Formula (I), where in W is. These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula (I) are useful in pharmaceuticals to treat diseases or conditions in which α7 is known to be involved.

  该发明提供了公式（I）的化合物，其中W是。这些化合物可以是药物盐或组合物，外消旋混合物或其纯对映体。公式（I）的化合物在制药学中用于治疗已知涉及α7的疾病或病症。
• AZABICYCLO AND AZACYCLO OXIME AND AMINE COMPOUNDS AS PESTICIDES
  申请人：Aventis CropScience GmbH

  公开号：EP1211940A1

  公开（公告）日：2002-06-12
• SUBSTITUTED AZABICYCLIC MOIETIES FOR THE TREATMENT OF DISEASE (NICOTINIC ACETHYLCHOLINE RECEPTOR ANTAGONISTS)
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1389208A1

  公开（公告）日：2004-02-18