3-[2-(azepan-1-yl)-1-(3,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-1-ylidene)-2-oxoethyl]quinoxalin-2(1H)-one | 1133326-48-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-[2-(azepan-1-yl)-1-(3,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-1-ylidene)-2-oxoethyl]quinoxalin-2(1H)-one
• CAS: 1133326-48-3
• 化学式: C₂₇H₃₀N₄O₂
• 分子量: 442.561
• InChiKey: XUJWQPCIABKWKM-GHVJWSGMSA-N

反应信息

• 作为产物：
  描述：

  1-(Azepane-1-carbonyl)-5,5-dimethyl-5,6-dihydro-pyrrolo[2,1-a]isoquinoline-2,3-dione 、 邻苯二胺 在 对甲苯磺酸 作用下， 以 异丙醇 为溶剂， 以82%的产率得到3-[2-(azepan-1-yl)-1-(3,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-1-ylidene)-2-oxoethyl]quinoxalin-2(1H)-one
  参考文献：
  名称：

  Synthesis of isoquinoline derivatives of quinoxalin-2-one from pyrrolo[2,1-a]isoquinoline-2,3-diones and o-phenylenediamine

  摘要：

  Reactions of 5,5-dialkyl-2,3,4,5-tetrahydropyrrolo[2,1-a]isoquinoline-2,3-diones with o-phenylenediamine in the presence of a catalytic amount of hydrogen chloride or p-toluenesulfonic acid involved opening of the pyrrole ring with formation of 3-(3,3-dialkyl-1,2,3,4-tetrahydroisoquinolin-1-ylidenemethyl)quinoxalin-2(1H)-ones. The presence of an enamine fragment in the products was confirmed by reaction with oxalyl chloride.

  DOI：

  10.1134/s1070428008060201