| 1417890-21-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• CAS: 1417890-21-1
• 化学式: C₃₇H₃₇N₅O₂
• 分子量: 583.733
• InChiKey: RSLFRTXMFDVEGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.75
• 重原子数：
  44.0
• 可旋转键数：
  8.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  64.17
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  、 mercury dichloride 以 aq. phosphate buffer 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Toward a highly sensitive and selective indole-rhodamine-based light-up probe for Hg 2+ and its application in living cells

  摘要：

  We herein designed and synthesized a light-up fluorescent probe L1 for Hg2+ species, which is based on indole derivative and Rhodamine fluorophore. The new probe can show a linear response to Hg2+ with high sensitivity and selectivity. As the Hg2+ concentration changed from 0 to 450 mu M, the fluorescence intensity of L1 at 575 nm changed from 50 to 6181 (similar to 120-fold). The detection limit of the probe was 5.0 x 10(-8) M. Besides, we have successfully applied L1 to monitor Hg2+ species in living MCF-7 cells by way of fluorescence imaging. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2017.06.024
• 作为产物：
  描述：

  罗丹明B 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 30.0h， 生成
  参考文献：
  名称：

  Toward a highly sensitive and selective indole-rhodamine-based light-up probe for Hg 2+ and its application in living cells

  摘要：

  We herein designed and synthesized a light-up fluorescent probe L1 for Hg2+ species, which is based on indole derivative and Rhodamine fluorophore. The new probe can show a linear response to Hg2+ with high sensitivity and selectivity. As the Hg2+ concentration changed from 0 to 450 mu M, the fluorescence intensity of L1 at 575 nm changed from 50 to 6181 (similar to 120-fold). The detection limit of the probe was 5.0 x 10(-8) M. Besides, we have successfully applied L1 to monitor Hg2+ species in living MCF-7 cells by way of fluorescence imaging. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2017.06.024

文献信息

• NIR- and FRET-Based Sensing of Cu²⁺ and S^2- in Physiological Conditions and in Live Cells
  作者：Chirantan Kar、Manab Deb Adhikari、Aiyagari Ramesh、Gopal Das

  DOI：10.1021/ic301872q

  日期：2013.1.18

  We have synthesized a new indole functionalized rhodamine derivative L-1 which specifically binds to Cu2+ in the presence of large excess of other competing ions with visually observable changes in their electronic and fluorescence spectral behavior. These spectral changes are significant enough in the NIR and visible region of the spectrum and thus enable naked eye detection. The receptor, L-1, could be employed as a resonance energy transfer (RET) based sensor for detection of Cu2+ based on the process involving the donor indole and the acceptor Cu2+ bound xanthene fragment. Studies reveal that L-1-Cu complex is selectively and fully reversible in presence of sulfide anions. Further, fluorescence microscopic studies confirmed that the reagent L-1 could also be used as an imaging probe for detection of uptake of these ions in HeLa cells.