1-碘-3-(2-苯基乙烯基)苯 | 81228-91-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 1-碘-3-(2-苯基乙烯基)苯
• 英文名称: 1-Iodo-3-(2-phenylethenyl)benzene
• CAS: 81228-91-3
• 化学式: C₁₄H₁₁I
• 分子量: 306.146
• InChiKey: ALMYMFCFNLMOPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  苯乙烯 、 碘苯 在 di-μ-acetatotetrakis(dihaptoethene)dirhodium(I) 、 copper(II) dipivaloate 、 三甲基乙酸 作用下， 反应 24.0h， 生成 苯,1-碘-4-(2-苯基乙烯基)- 、 1-碘-3-(2-苯基乙烯基)苯
  参考文献：
  名称：

  铑催化芳烃有氧烯基化反应合成二苯乙烯

  摘要：

  芳烃烯基化通常通过后期过渡金属介导的 C(sp2)-C(sp2) 交叉偶联实现，但该策略通常需要预官能化底物（例如，具有卤化物或拟卤化物）和/或在芳烃。过渡金属介导的芳烃 CH 活化和烯基化提供了一种功能化芳烃底物的替代方法。在此，我们报告了由芳烃和苯乙烯进行铑催化氧化芳烃烯基化以制备二苯乙烯和二苯乙烯衍生物。芳烃和烯烃上的几个官能团（包括氟化物、氯化物、三氟甲基、酯、硝基、乙酸酯、氰化物和醚基团）的反应是成功的。单取代芳烃的反应对间位和对位的烯基化具有选择性，通常具有大约 2 个：1 选择性，分别。白藜芦醇和 (E)-1,2,3-三甲氧基-5-(4-甲氧基苯乙烯基)苯 (DMU-212) 是通过这种单步方法以高产率合成的。与钯催化的比较表明，铑催化对单取代芳烃的间位官能化具有更高的选择性，并且Rh催化对卤素基团的耐受性更好。

  DOI：

  10.1021/jacs.0c03935

文献信息

• Halocombstatins and methods of synthesis thereof
  申请人：Pettit R. George

  公开号：US20050176688A1

  公开（公告）日：2005-08-11

  The invention relates to novel compounds denominated halocombstatins. The halocombstatins are derivatives of combretastatin A-3, and include compounds that exhibit cancer growth cell inhibition against a panel of human cancer cell lines and the murine P388 leukemia, as well as activity as inhibitors of tubulin polymerization and inhibitors of the binding of colchicine to tubulin.

  这项发明涉及一种名为卤化康柏斯塔汀（halocombstatins）的新化合物。卤化康柏斯塀是康柏斯塀A-3的衍生物，包括对一系列人类癌细胞系和小鼠P388白血病表现出癌细胞生长抑制作用的化合物，以及作为微管聚合抑制剂和结合秋水仙碱对微管的抑制剂的活性。
• Process for the preparation of alkenylbenzene derivatives or
  申请人：Ciba-Geigy Corporation

  公开号：US04335055A1

  公开（公告）日：1982-06-15

  Compounds of the formula I ##STR1## in which Z, Z.sub.1, R, m and p are as defined in patent claim 1, can be obtained in a simple and economical manner by a novel process wherein a halide of the formula II ##STR2## is reacted with a substituted or unsubstituted vinylbenzene or vinylnaphthalene derivative in the presence of a base and of certain palladium catalysts, such as palladium acetate. The compounds (I) or functional derivatives preparable therefrom are useful, for example, for the preparation of known dyes or fluorescent brighteners, or can be used directly as fluorescent brighteners or as scintillators.

  式I的化合物##STR1##中，其中Z，Z.sub.1，R，m和p如专利权要求1所定义，可以通过一种新的方法简单经济地获得，其中式II的卤化物##STR2##在碱和某些钯催化剂（例如乙酸钯）的存在下与取代或未取代的乙烯基苯或乙烯基萘衍生物反应。可以利用从化合物（I）或可制备的功能衍生物，例如制备已知的染料或荧光增白剂，或可直接用作荧光增白剂或闪烁体。
• HALOCOMBSTATINS AND METHODS OF SYNTHESIS THEREOF
  申请人：Pettit R. George

  公开号：US20070167412A1

  公开（公告）日：2007-07-19

  The invention relates to novel compounds denominated halocombstatins. The halocombstatins are derivatives of combretastatin A-3, and include compounds that exhibit cancer growth cell inhibition against a panel of human cancer cell lines and the murine P388 leukemia, as well as activity as inhibitors of tubulin polymerization and inhibitors of the binding of colchicine to tubulin.

  本发明涉及一种新型化合物，称为卤代联合斯达汀。卤代联合斯达汀是联合斯达汀A-3的衍生物，包括对一系列人类癌细胞系和小鼠P388白血病的癌细胞生长抑制作用以及作为微管聚合抑制剂和秋水仙碱结合到微管的抑制剂的化合物。
• RADIATION CURABLE PHOTOCHROMIC INKS
  申请人：Iftime Gabriel

  公开号：US20070211110A1

  公开（公告）日：2007-09-13

  An ink that may be used in ink jet devices is a photochromic ink comprising an ink vehicle that includes at least one radiation curable component, at least one photochromic material and at least one photoinitiator. The ink is cured via exposure to radiation that cures the at least one radiation curable component of the ink. A radiation curable ink capable of exhibiting photochromatic color changes, which may be used to indicate a document's authenticity, is thus achieved.
• USE OF APPENDED DYES IN OPTICAL DATA STORAGE MEDIA
  申请人：Natarajan Arunkumar

  公开号：US20120052232A1

  公开（公告）日：2012-03-01

  The present disclosure relates to optical media and the formation and use of such media. In certain embodiments the optical media or a composition suitable for such media includes a polymeric matrix or substrate. A dye, such as an energy transfer dye is chemically appended to the polymeric matrix or substrate, such as by one or more covalent bonds.