4-羟基苯基乙醛肟 | 23745-82-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 4-羟基苯基乙醛肟
• 中文别名: N-(2-羟基四氢噻吩-3-基)乙酰胺
• 英文名称: 4-hydroxyphenylacetaldehyde oxime
• 英文别名: 4-hydroxyphenylacetaldoxime；p-hydroxyphenylacetaldoxime；-p-Hydroxyphenyl-acetaldoxim；p-Hydroxyphenylacetadehyd-oxim；p-Hydroxy-phenylacetaldoxim；p-Hydroxyphenylacetaldoxim；(4-Hydroxyphenyl)acetaldehyde oxime；4-(2-hydroxyiminoethyl)phenol
• CAS: 23745-82-6
• 化学式: C₈H₉NO₂
• 分子量: 151.165
• InChiKey: TVXJJNJGTDWFLD-UHFFFAOYSA-N

物化性质

• 熔点：
  110-111 °C(Solv: chloroform (67-66-3))
• 沸点：
  358.8±25.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  52.8
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  4-羟基苯基乙醛肟 在 [双(三氟乙酰氧基)碘]苯 作用下， 以 乙腈 为溶剂， 以20%的产率得到1-oxa-2-azaspiro<4.5>deca-2,6,9-trien-8-one
  参考文献：
  名称：

  Kacan, Mesut; Koyuncu, Demet; McKillop, Alexander, Journal of the Chemical Society. Perkin transactions I, 1993, # 15, p. 1771 - 1776

  摘要：

  DOI：
• 作为产物：
  描述：

  DL-酪氨酸 在 cytochrome P₄₅₀ CYP₇₉A₁ 作用下， 生成 4-羟基苯基乙醛肟
  参考文献：
  名称：

  Expression and membrane-targeting of an active plant cytochrome P450 in the chloroplast of the green alga Chlamydomonas reinhardtii

  摘要：

  The unicellular green alga Chlamydomonas reinhardtii has potential as a cell factory for the production of recombinant proteins and other compounds, but mainstream adoption has been hindered by a scarcity of genetic tools and a need to identify products that can be generated in a cost-effective manner. A promising strategy is to use algal chloroplasts as a site for synthesis of high value bioactive compounds such as diterpenoids since these are derived from metabolic building blocks that occur naturally within the organelle. However, synthesis of these complex plant metabolites requires the introduction of membrane-associated enzymes including cytochrome P450 enzymes (P450s). Here, we show that a gene (CYP79A1) encoding a model P450 can be introduced into the C reinhardtii chloroplast genome using a simple transformation system. The gene is stably expressed and the P450 is efficiently targeted into chloroplast membranes by means of its endogenous N-terminal anchor domain, where it is active and accounts for 0.4% of total cell protein. These results provide proof of concept for the introduction of diterpenoid synthesis pathways into the chloroplast of C. reinhardtii. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2014.12.006

文献信息

• Cytochrome P450 monooxygenases
  申请人：——

  公开号：US20030041346A1

  公开（公告）日：2003-02-27

  Cytochrome P450 II dependent monooxygenases and DNA molecules encoding these monooxygenases are provided, which are able to catalyze the biosynthethic conversion of aldoximes to nitrils and the conversion of said nitrils to the corresponding cyanohydrins, which are the presursors of cyanogenic glycosides. Moreover, the invention provides methods for obtaining DNA molecules according to the invention and methods for obtaining transgenic plants resistant to insects, acarids, or nematodes or plants with improved nutritive value.

  本发明提供了依赖于细胞色素P450II的单加氧酶和编码这些单加氧酶的DNA分子，这些单加氧酶能够催化醛肟的生物合成转化为腈和将所述腈转化为相应的氰醇，这些是青霉素糖苷的前体。此外，本发明还提供了根据本发明获得DNA分子的方法和获得对昆虫、螨虫或线虫具有抗性或具有改善营养价值的转基因植物的方法。
• Expression and membrane-targeting of an active plant cytochrome P450 in the chloroplast of the green alga Chlamydomonas reinhardtii
  作者：Doris Gangl、Julie A.Z. Zedler、Artur Włodarczyk、Poul Erik Jensen、Saul Purton、Colin Robinson

  DOI：10.1016/j.phytochem.2014.12.006

  日期：2015.2

  The unicellular green alga Chlamydomonas reinhardtii has potential as a cell factory for the production of recombinant proteins and other compounds, but mainstream adoption has been hindered by a scarcity of genetic tools and a need to identify products that can be generated in a cost-effective manner. A promising strategy is to use algal chloroplasts as a site for synthesis of high value bioactive compounds such as diterpenoids since these are derived from metabolic building blocks that occur naturally within the organelle. However, synthesis of these complex plant metabolites requires the introduction of membrane-associated enzymes including cytochrome P450 enzymes (P450s). Here, we show that a gene (CYP79A1) encoding a model P450 can be introduced into the C reinhardtii chloroplast genome using a simple transformation system. The gene is stably expressed and the P450 is efficiently targeted into chloroplast membranes by means of its endogenous N-terminal anchor domain, where it is active and accounts for 0.4% of total cell protein. These results provide proof of concept for the introduction of diterpenoid synthesis pathways into the chloroplast of C. reinhardtii. (C) 2014 Elsevier Ltd. All rights reserved.
• Kacan, Mesut; Koyuncu, Demet; McKillop, Alexander, Journal of the Chemical Society. Perkin transactions I, 1993, # 15, p. 1771 - 1776
  作者：Kacan, Mesut、Koyuncu, Demet、McKillop, Alexander

  DOI：——

  日期：——