5β-cholan-24-oic acid propyl ester | 77617-18-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 5β-cholan-24-oic acid propyl ester
• 英文别名: 5β-Cholan-24-saeure-propylester；5β-Cholansaeure-(24)-propylester
• CAS: 77617-18-6
• 化学式: C₂₇H₄₆O₂
• 分子量: 402.661
• InChiKey: FYDWWEWVTUHBDR-FEKPLHOGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  29.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  3,7-二酮-5Β-胆甾烷-24-酸 在 盐酸 、 amalgamated zinc 、 硫酸 、 溶剂黄146 作用下， 生成 5β-cholan-24-oic acid propyl ester
  参考文献：
  名称：

  Serum leptin levels are not influenced by arginine and insulin infusion and by acute changes of GH

  摘要：

  The aim of this study was to evaluate the relationship between GH and leptin in a group of short children and adolescents. Leptin and GH serum levels were measured before and during pharmacological stimulation tests (arginine and insulin) in a group of 45 children (30 male, 15 female), mean age 8.6+/-3.9 yr, affected by idiopathic isolated GH deficiency (GHD), and in a group of 27 children (115 male, 12 female), age 10.9 +/- 3.3 yr, with constitutional growth delay. Results showed that basal and peak leptin levels as well as the AUC were significantly higher in GHD patients compared to controls (p<0.05) and correlated with BMI SDS (p<0.0001) in GHD patients. No change in leptin serum levels was observed during either stimulation test. No correlation was found, however, between basal leptin serum levels and basal, peak and the AUC of GH during the tests. Moreover, no correlation was found between the acute changes of serum GH concentration during both stimulation tests and leptin serum levels. The results suggest that leptin and GH secretion is not correlated and that leptin serum levels mainly reflect the amount of fat tissue, which is higher in GHD patients.

  DOI：

  10.1007/bf03345510

文献信息

• Takeda; Igarashi, Journal of Biochemistry, 1959, vol. 46, p. 1313,1317
  作者：Takeda、Igarashi

  DOI：——

  日期：——