2,3-Bis(3-hydroxyphenyl)quinoxalin-6-ol | 1310679-68-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2,3-Bis(3-hydroxyphenyl)quinoxalin-6-ol
• 英文别名: 2,3-bis(3-hydroxyphenyl)quinoxalin-6-ol
• CAS: 1310679-68-5
• 化学式: C₂₀H₁₄N₂O₃
• 分子量: 330.343
• InChiKey: MMPJUGQEIFUORK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  86.5
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-Methoxy-2,3-bis(3-methoxyphenyl)quinoxaline 在 乙硫醇钠 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 2,3-Bis(3-hydroxyphenyl)quinoxalin-6-ol
  参考文献：
  名称：

  Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors

  摘要：

  A library of quinoxaline derivatives were prepared to target non-structural protein 1 of influenza A (NS1A) as a means to develop anti-influenza drug leads. An in vitro fluorescence polarization assay demonstrated that these compounds disrupted the dsRNA-NS1A interaction to varying extents. Changes of substituent at positions 2, 3 and 6 on the quinoxaline ring led to variance in responses. The most active compounds (35 and 44) had IC50 values in the range of low micromolar concentration without exhibiting significant dsRNA intercalation. Compound 44 was able to inhibit influenza A/Udorn/72 virus growth. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.042

文献信息

• POLYMERIZABLE LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION FOR OPTICAL ELEMENT, POLYMER, OPTICALLY ANISOTROPIC BODY, AND OPTICAL ELEMENT FOR DISPLAY DEVICE
  申请人：LG CHEM, LTD.

  公开号：EP3789472A1

  公开（公告）日：2021-03-10

  A polymerizable liquid crystal compound represented by Chemical Formula 1, a liquid crystal composition for an optical element comprising the same, a polymer polymerized from the same, an optically anisotropic body comprising a cured material or polymerized reactant of the liquid crystal composition or the polymer, and an optical element for a display device comprising the optical anisotropic body are disclosed herein.

  本文公开了一种由化学式 1 表示的可聚合液晶化合物、一种用于光学元件的液晶组合物（包含该液晶组合物）、一种由该液晶组合物聚合而成的聚合物、一种光学各向异性体（包含该液晶组合物或该聚合物的固化材料或聚合反应物）以及一种用于显示设备的光学元件（包含该光学各向异性体）。
• Polymerizable Liquid Crystal Compound, Liquid Crystal Composition for Optical Element, Polymer, Optically Anisotropic Body, and Optical Element for Display Device
  申请人：LG Chem, Ltd.

  公开号：US20210062092A1

  公开（公告）日：2021-03-04

  A polymerizable liquid crystal compound represented by Chemical Formula 1, a liquid crystal composition for an optical element comprising the same, a polymer polymerized from the same, an optically anisotropic body comprising a cured material or polymerized reactant of the liquid crystal composition or the polymer, and an optical element for a display device comprising the optical anisotropic body are disclosed herein.
• Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors
  作者：Lei You、Eun Jeong Cho、John Leavitt、Li-Chung Ma、Gaetano T. Montelione、Eric V. Anslyn、Robert M. Krug、Andrew Ellington、Jon D. Robertus

  DOI：10.1016/j.bmcl.2011.03.042

  日期：2011.5

  A library of quinoxaline derivatives were prepared to target non-structural protein 1 of influenza A (NS1A) as a means to develop anti-influenza drug leads. An in vitro fluorescence polarization assay demonstrated that these compounds disrupted the dsRNA-NS1A interaction to varying extents. Changes of substituent at positions 2, 3 and 6 on the quinoxaline ring led to variance in responses. The most active compounds (35 and 44) had IC50 values in the range of low micromolar concentration without exhibiting significant dsRNA intercalation. Compound 44 was able to inhibit influenza A/Udorn/72 virus growth. (C) 2011 Elsevier Ltd. All rights reserved.