(4-dimethylamino-benzyliden)-urea | 623927-11-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (4-dimethylamino-benzyliden)-urea
• 英文别名: (4-Dimethylamino-benzyliden)-harnstoff；p-Dimethylaminobenzylidene urea；[4-(dimethylamino)phenyl]methylideneurea
• CAS: 623927-11-7
• 化学式: C₁₀H₁₃N₃O
• 分子量: 191.233
• InChiKey: HKSNGBKERRRBJF-UHFFFAOYSA-N

物化性质

• 熔点：
  147 °C
• 沸点：
  353.3±44.0 °C(Predicted)
• 密度：
  1.10±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  58.7
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4-dimethylamino-benzyliden)-urea 在 双氧水 作用下， 以 水 为溶剂， 反应 6.0h， 生成 结晶紫内酯
  参考文献：
  名称：

  结晶紫内酯的合成方法

  摘要：

  结晶紫内酯的合成方法，涉及一种热压敏染料的合成方法，以尿素、二甲基苯胺、间二甲氨基苯甲酸、对二甲氨基苯甲醛等物质为原料进行合成，经过席夫碱阶段、尿素中间体阶段、无色结晶紫阶段和最后的氧化反应阶段，合成结晶紫内酯。合成方法包括阶段：（1）席夫碱阶段：对二甲氨基苯甲醛和尿素反应生成席夫碱；（2）尿素中间体阶段：上一阶段生成产物和二甲基苯胺反应得到尿素中间体；（3）无色结晶紫内酯阶段：尿素中间体和间二甲氨基苯甲酸为原料反应生成无色结晶紫；（4）氧化反应阶段：无色结晶紫经过氧化氢催化氧化生成结晶紫内酯。该方法为避免杂质生成的合成方法，从而提高了产品的收率，同时减少了固体废料的排放。

  公开号：

  CN106565650B
• 作为产物：
  描述：

  对二甲氨基苯甲醛 、 尿素 在 Amberlite IRA-400 Cl anion exchange resin 作用下， 以 neat (no solvent) 为溶剂， 生成 (4-dimethylamino-benzyliden)-urea
  参考文献：
  名称：

  以Amberlite IRA-400 Cl树脂为绿色催化剂的一锅多组分合成萘并恶嗪-3-酮衍生物

  摘要：

  一种高效的Amberlite IRA-400 Cl树脂通过以下反应催化无溶剂一锅合成1-芳基-1,2-二氢-3H-萘[1,2-e] [1,3]恶嗪-3-酮描述了芳基醛，脲和β-萘酚的三组分反应。该方法具有诸如后处理容易，对环境的影响小，反应时间短和产率高的优点。回收的催化剂可重复使用四次，而催化活性没有明显损失。

  DOI：

  10.2174/1570178614666170811151040

文献信息

• Bellavita; Cagnoli, Gazzetta Chimica Italiana, 1939, vol. 69, p. 583,592
  作者：Bellavita、Cagnoli

  DOI：——

  日期：——
• Barrenscheen, Biochemische Zeitschrift, 1923, vol. 140, p. 429,430
  作者：Barrenscheen

  DOI：——

  日期：——
• Bellavita; Cagnoli, Gazzetta Chimica Italiana, 1939, vol. 69, p. 602,608
  作者：Bellavita、Cagnoli

  DOI：——

  日期：——
• O-Carbamoyl oximes
  作者：David R. Dalton、H. Grant Foley

  DOI：10.1021/jo00963a022

  日期：1973.11
• Impact of gender and having children in the household on ambulatory blood pressure in work and nonwork settings: A partial replication and new findings
  作者：Christine A. Marco、Joseph E. Schwartz、John M. Neale、Saul Shiffman、Delwyn Catley、Arthur A. Stone

  DOI：10.1007/bf02895773

  日期：2000.6

  Ambulatory blood pressure (ABP) has been shown to differ for men and women across work and nonwork settings. For men, ABP is higher at work than at home on workdays or on nonworkdays. For women, ABP levels in different settings depend on whether they have children in the household. Women without children at home exhibit the "male" pattern of higher ABP at work than at home. Women with children at home show either similar ABP levels in the two locations or higher ABP at home. These different patterns have been assumed to represent different stress levels in the two locations, but this assumption has rarely been tested. Also, few studies have examined ABP levels on a nonworkday in women or the effect of having children in the household for men. The present study monitored ABP in men and women during two workdays and one nonworkday. Comparisons were made between ABP levels in three settings (workday at work, workday at home, nonworkday) using mixed random effects regression models. Psychosocial variables (e.g. mood, stress) that might mediate the different ABP patterns were also assessed. ABP differences were analyzed by gender and whether children were living in the household using mixed random effects regression models. Results indicated that diastolic blood pressure was higher at work versus home for men with children and higher at work and on nonworkdays than at home for women without children. ABP did not differ across settings for women with children or men without children. These results were not mediated by mood or stress levels in the three settings.