N-(2,6-diethylphenyl)phthalimide | 53034-44-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-(2,6-diethylphenyl)phthalimide
• 英文别名: 2-(2,6-Diethylphenyl)isoindole-1,3-dione
• CAS: 53034-44-9
• 化学式: C₁₈H₁₇NO₂
• 分子量: 279.338
• InChiKey: SWUDAFKDZAPOTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2,6-diethylphenyl)phthalimide 、 2,6-二乙基苯胺 生成 2-(2,6-diethyl-phenyl)-isoindolin-1-one
  参考文献：
  名称：

  IVATA, MITIAKI;KAI, FUMIO;SUDZUKI, SATIO;VATANABEH, TEHTSURO;SEHKIDZAVA, +

  摘要：

  DOI：
• 作为产物：
  描述：

  苯酐 、 2,6-二乙基苯胺 反应 0.14h， 以78%的产率得到N-(2,6-diethylphenyl)phthalimide
  参考文献：
  名称：

  2-Aryl-1H-Isoindole-1,3-Dione 库的微波辅助平行合成

  摘要：

  描述了具有代表性的 28 成员邻苯二甲酰亚胺库的有效并行合成。平行层析以合适的纯度和高产率提供文库成员。

  DOI：

  10.1055/s-2002-19765

文献信息

• Specific inhibitor of puromycin-sensitive aminopeptidase with a homophthalimide skeleton: identification of the target molecule and a structure–activity relationship study
  作者：Masato Komoda、Hiroki Kakuta、Hiroyasu Takahashi、Yasuyuki Fujimoto、Shizuo Kadoya、Fuminori Kato、Yuichi Hashimoto

  DOI：10.1016/s0968-0896(00)00231-5

  日期：2001.1

  ,3-dione (2: PIQ-22) was found to be a potent and specific inhibitor of puromycin-sensitive aminopeptidase (PSA). Lineweaver-Burk plot analysis showed that PSA is inhibited by PIQ-22 in a non-competitive manner. Structure -activity relationship studies indicated that tautomerism of the imidobenzoylketone group in the cyclic imide moiety of the PIQ-22 skeleton is important for the inhibitory activity

  发现2-（2，6-二乙基苯基）-1，2，3，4-四氢异喹啉-1，3-二酮（2：PIQ-22）是嘌呤霉素敏感性氨基肽酶（PSA）的有效和特异性抑制剂。Lineweaver-Burk图分析表明，PSA被PIQ-22抑制为非竞争性方式。结构-活性关系研究表明，PIQ-22骨架的环状酰亚胺部分中的亚氨基苯甲酰基酮基的互变异构对于抑制活性很重要。
• PROCESS FOR PREPARATION OF STABLE, MICROENCAPSULATED AND SUSTAINED RELEASE BIOCIDAL ACTIVES AND COMPOSITION THEREOF
  申请人：Premachandran Raman

  公开号：US20120164203A1

  公开（公告）日：2012-06-28

  Disclosed herein is a process for the preparation of a stable sustained-release biocidal composition containing microencapsulated biocide and wherein the process comprises the steps of: (i) adsorbing the biocide onto an inert carrier by grinding to attain the required particle size and wherein the ratio of biocide; inert carrier is in the range of about 1:99 to about 99:1 (ii) optionally coating with an appropriate amine or imine compound or a water resistant film forming polymer and dispersing the resultant biocide encapsulated inert carrier in an aqueous medium in the presence of suitable dispersing agent (iii) adding at least one thickening agent to re-disperse the encapsulated biocide containing partial amount of non-encapsulated biocide if any and (iv) preparing an aqueous or solvent based sustained release biocide dispersion. Also disclosed is a stable, sustained-release biocidal composition prepared by such process and uses thereof.

  本文揭示了一种制备稳定的持续释放生物杀菌剂组合物的方法，其中包含微囊化生物杀菌剂，所述方法包括以下步骤：(i)通过研磨将生物杀菌剂吸附到惰性载体上，以达到所需的粒径，其中生物杀菌剂；惰性载体的比例在约1:99至约99:1的范围内；(ii)可选地用适当的胺或亚胺化合物或耐水膜形成聚合物进行包覆，并在适当的分散剂存在下将所得的生物杀菌剂微囊化惰性载体分散在水性介质中；(iii)添加至少一种增稠剂以重新分散含有任何非微囊化生物杀菌剂的微囊化生物杀菌剂，(iv)制备基于水性或溶剂的持续释放生物杀菌剂分散液。还揭示了通过这种方法制备的稳定的持续释放生物杀菌剂组合物及其用途。
• Synthesis of <i>N</i>-substituted phthalimides <i>via</i> Pd-catalyzed [4+1] cycloaddition reaction
  作者：Chengxian Hu、Lu Wang、Yuanyuan Wu、Yonglong Zheng、Ying Fu、Zhengyin Du

  DOI：10.1039/d3cc04534j

  日期：——

  A novel Pd-catalyzed assembly of N-phenylphthalimide by merging of [4+1] cycloaddition and difluorocarbene transfer carbonylation from 2-iodo-N-phenylbenzamides and difluorocarbene precursors is disclosed. In this reaction, difluorocarbene acts as a carbonyl source and simultaneously forms one C-C bond, one C-N bond and one C=O bond to produce N-phenylphthalimides in high yields.

  公开了一种新颖的 Pd 催化的 N-苯基邻苯二甲酰亚胺组装方法，通过合并 [4+1] 环加成和来自 2-碘-N-苯基苯甲酰胺和二氟卡宾前体的二氟卡宾转移羰基化。在此反应中，二氟卡宾作为羰基源，同时形成1个CC键、1个CN键和1个C=O键，以高产率生成N-苯基邻苯二甲酰亚胺。
• Fluorophthalimides
  申请人：MEIJI SEIKA KABUSHIKI KAISHA

  公开号：EP0245989A2

  公开（公告）日：1987-11-19

  Fluorophthalimide compounds represented by the following general formula (I): wherein R each stands for an ethyl group or an isopropyl group, are effective for controlling diseases of agricultural plants, especially diseases caused by microorganisms belonging to the genus Rhizoctonia, represented by sheath blight of rice plants, and diseases caused by Basidomycetes.

  由以下通式(I)代表的氟邻苯二甲酰亚胺化合物： 其中 R 分别代表一个乙基或一个异丙基，可有效防治农业植物的病害，特别是由根瘤菌属微生物引起的病害（以水稻鞘枯病为代表）和由担子菌引起的病害。
• Benzenesulfonanilide derivatives and fungicides for agriculture and horticulture
  申请人：HOKKO CHEMICAL INDUSTRY CO., LTD

  公开号：EP0306222A2

  公开（公告）日：1989-03-08

  A benzenesulfonailide derivative of formula (I) is disclosed wherein R represents (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C1-C6)-haloalkyl, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl, ( C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C6)-alkyl, phenyl or phenyl-(C1-C6)-alkyl, n is 0, 1 or 2, X represents hydrogen or halogen and Y represents hydrogen, halogen, nitro, (C1-C6)-alkylthio, (C1-C6)-alkylsulfinyl or (C1-C6)-alkylsulfonyl. Also disclosed is a fungicide for agriculture and horticulture containing as its active ingredient the derivative of formula (I).

  公开了一种式(I)的苯磺酰亚胺衍生物，其中 R 代表(C1-C6)-烷基、(C2-C6)-烯基、(C2-C6)-炔基、(C1-C6)-卤代烷基、(C1-C6)-烷氧基-(C1-C6)-烷基、(C1-C6)-烷氧基羰基-(C1-C6)-烷基、( C3-C6)-环烷基、(C3-C6)-环烷基-(C1-C6)-烷基、苯基或苯基-(C1-C6)-烷基、(C3-C6)-环烷基-(C1-C6)-烷基、苯基或苯基-(C1-C6)-烷基，n 为 0、1 或 2，X 代表氢或卤素，Y 代表氢、卤素、硝基、(C1-C6)-烷硫基、(C1-C6)-烷基亚磺酰基或(C1-C6)-烷基磺酰基。还公开了一种农业和园艺用杀真菌剂，其活性成分含有式 (I) 衍生物。