N-[(2-hydroxynaphthalen-1-yl)(4-methoxyphenyl)methyl]acrylamide | 1122094-00-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[(2-hydroxynaphthalen-1-yl)(4-methoxyphenyl)methyl]acrylamide
• 英文别名: N-[(2-hydroxynaphthalen-1-yl)-(4-methoxyphenyl)methyl]prop-2-enamide
• CAS: 1122094-00-1
• 化学式: C₂₁H₁₉NO₃
• 分子量: 333.387
• InChiKey: AYBWCHSMQXYCKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲氧基苯甲醛 、 丙烯酰胺 、 2-萘酚 在 三聚氯氰 作用下， 反应 0.42h， 以93%的产率得到N-[(2-hydroxynaphthalen-1-yl)(4-methoxyphenyl)methyl]acrylamide
  参考文献：
  名称：

  在无溶剂条件下由2,4,6-三氯-1,3,5-三嗪催化三组分反应制备酰胺基烷基萘

  摘要：

  摘要描述了酰胺烷基萘的有效的一锅法合成。这涉及2-萘酚，芳族醛和酰胺或脲在催化剂量的2,4,6-三氯-1,3,5-三嗪（TCT，氰尿酰氯）存在下的三组分反应。免费条件。 图形概要

  DOI：

  10.1007/s00706-008-0059-5

文献信息

• β-Cyclodextrin-butane sulfonic acid: an efficient and reusable catalyst for the multicomponent synthesis of 1-amidoalkyl-2-naphthols under solvent-free conditions
  作者：Kai Gong、Hualan Wang、Xiaoxue Ren、Ying Wang、Jinghua Chen

  DOI：10.1039/c5gc00384a

  日期：——

  A [small beta]-cyclodextrin-butane sulfonic acid is reported as an efficient catalyst for the one-pot synthesis of 1-amidoalkyl-2-naphthols by the multicomponent condensation of aromatic aldehydes, [small beta]-naphthol and amides under solvent-free conditions. The...

  据报道，小α-环糊精-丁磺酸是在溶剂-溶剂下通过芳香醛，小-萘酚和酰胺的多组分缩合一锅合成1-氨基烷基-2-萘的有效催化剂。免费条件。这...
• Nano Silica Sulfuric Acid an Efficient and Recoverable Heterogeneous Catalyst for the Preparation of Amidoalkyl Naphthols Under Solvent-Free Conditions
  作者：Keivan Ghodrati、Azita Farrokhi、Changiz Karami、Zohre Hamidi

  DOI：10.1080/15533174.2013.809746

  日期：2015.1.2

  An efficient and green method has been developed for the synthesis of amidoalkyl naphthol derivatives through a one-pot three-component condensation of 2-naphthol, aldehydes, and amide in the presence of nano silica sulfuric acid as heterogeneous catalyst under solvent-free conditions.

  在无溶剂条件下，以纳米二氧化硅硫酸为多相催化剂，在2-萘酚，醛和酰胺的一锅式三组分缩合反应中，开发了一种高效的绿色方法，用于合成氨基烷基萘酚衍生物。
• Strontium(II) Triflate Catalysed Condensation of β-Naphthol, Aldehyde and Urea or Amides: A Facile Synthesis of Amidoalkyl Naphthols
  作者：Weike Su、Wenyuan Tang、Jianjun Li

  DOI：10.3184/030823408x298508

  日期：2008.3

  A novel and efficient synthesis of amidoalkyl naphthols has been developed by one-pot condensation of β-naphthol, aromatic aldehydes and urea or amides in the presence of strontium(II) triflate as a catalyst in high yields.

  在三氟甲磺酸锶 (II) 作为催化剂的存在下，通过 β-萘酚、芳香醛和尿素或酰胺的一锅缩合，开发了一种新型高效的酰氨基烷基萘酚合成方法。
• Thiamine hydrochloride as a efficient catalyst for the synthesis of amidoalkyl naphthols
  作者：Min Lei、Lei Ma、Lihong Hu

  DOI：10.1016/j.tetlet.2009.08.081

  日期：2009.11

  A simple, efficient, and practical procedure for the synthesis of amidoalkyl naphthols using thiamine hydrochloride (VB1) as a novel catalyst is described in high yields. The salient features of the catalyst are efficiency, inexpensiveness, non-toxicity, and metal ion free. (C) 2009 Elsevier Ltd. All rights reserved.