3-(2-bromophenyl)butanoic acid | 66192-08-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-(2-bromophenyl)butanoic acid
• CAS: 66192-08-3
• 化学式: C₁₀H₁₁BrO₂
• mdl: MFCD18380592
• 分子量: 243.1
• InChiKey: GOMRPAZFPUTDBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(2-bromophenyl)butanoic acid 在 lithium aluminium tetrahydride 、 氯化亚砜 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 3-(2-bromophenyl)butan-1-ol
  参考文献：
  名称：

  [EN] ANTI-HCMV COMPOSITIONS AND METHODS
  [FR] COMPOSITIONS ANTI-HCMV ET PROCÉDÉS

  摘要：

  公开号：

  WO2016077240A3
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 3-(2-bromophenyl)butanoic acid
  参考文献：
  名称：

  Synthesis of 8-Bromo-1-Methylnaphthalene from o-Bromoacetophenone

  摘要：

  DOI：

  10.1021/jo01360a005

文献信息

• Substituted aryl or heteroarylpiperidine derivatives as melanocortin-4 receptor modulators
  申请人：Santhera Pharmaceuticals (Schweiz) AG

  公开号：EP2020405A1

  公开（公告）日：2009-02-04

  The present invention relates to substituted aryl or heteroarylpiperidine derivatives of structure (I) as melanocortin-4 receptor modulators. Depending on the structure and the stereochemistry the compounds of the invention are either selective agonists or selective antagonists of the human melanocortin-4 receptor (MC-4R). The agonists can be used for the treatment of disorders and diseases such as obesity, diabetes and sexual dysfunction, whereas the antagonists are useful for the treatment of disorders and diseases such as cancer cachexia, muscle wasting, anorexia, anxiety and depression. Generally all diseases and disorders where the regulation of the MC-4R is involved can be treated with the compounds of the invention.

  本发明涉及结构式(I)的取代芳基或杂芳基哌啶衍生物，作为黑色素皮质素-4受体调节剂。根据结构和立体化学，本发明的化合物可以是人类黑色素皮质素-4受体(MC-4R)的选择性激动剂或选择性拮抗剂。激动剂可用于治疗肥胖、糖尿病和性功能障碍等疾病，而拮抗剂可用于治疗癌症恶病质、肌肉消耗、厌食症、焦虑和抑郁等疾病。一般来说，所有涉及MC-4R调节的疾病和疾病都可以用本发明的化合物进行治疗。
• Catalyst component for the polymerization of .alpha.-olefins and a
  申请人：Mitsubishi Chemical Corporation

  公开号：US05594081A1

  公开（公告）日：1997-01-14

  The present invention provides a catalyst for polymerizing an .alpha.-olefin which is capable of producing an .alpha.-olefin polymer having a high molecular weight in a high yield under the polymerization conditions including at high temperature, and a process for preparing an .alpha.-olefin polymer, which catalyst comprises a Component (A) which comprises a coordination compound having a skeleton of a metallocene compound comprising an indenyl ring or a hydroindenyl ring which is an indenyl having a six-membered portion hydrogenated as a ligand and having Ti, Zr or Hf as a metal component in combination with a Component (B) which is, for example, an alumoxane. The coordination compound is crosslinked at the six-membered rings characterized by the fact that two of the indenyl or hydroindenyl groups are crosslinked at the six-membered ring of the indenyl or hydroindenyl group.

  本发明提供了一种催化剂，用于聚合能够在高温条件下产生高分子量α-烯烃聚合物的α-烯烃，并且在聚合条件下高产率，以及一种制备α-烯烃聚合物的方法，该催化剂包括组分（A），其包括具有金属茂化合物骨架的配位化合物，该金属茂化合物包括一个具有六元环部分氢化的茚基环或氢茚基环的茂基环作为配体，并且具有Ti、Zr或Hf作为金属组分，与组分（B），例如铝氧烷，结合使用。该配位化合物在六元环上交联，其特征在于两个茚基或氢茚基组分在茚基或氢茚基组分的六元环上交联。
• Catalysts for olefin polymerization and a process for preparing olefin
  申请人：Mitsubishi Chemical Corporation

  公开号：US05942459A1

  公开（公告）日：1999-08-24

  The object of the present invention is to provide a polyolefin having a good particle property in a high yield without use of an expensive alumoxane. The present invention comprises a catalyst for olefin polymerization comprising the following ingredients (A), (B) and (C), and a process for preparing an olefin polymer with use of the catalyst: Component (A): a transition metal compound having at least one conjugated five-membered ring ligand, the transition metal being in the Groups IV-VI of the Periodic Table, Component (B): an organoaluminum compound, and Component (C): a finely divided particle composition comprising 0.1-99.9% by weight of boric acid.

  本发明的目的是提供一种聚烯烃，其具有良好的颗粒特性，且不需要使用昂贵的氧化铝。本发明包括用于烯烃聚合的催化剂，该催化剂包括以下成分（A）、（B）和（C），以及使用该催化剂制备烯烃聚合物的方法：组分（A）：至少具有一个共轭五元环配体的过渡金属化合物，该过渡金属位于周期表的IV-VI族，组分（B）：有机铝化合物，以及组分（C）：包含0.1-99.9重量％硼酸的细粉末组成。
• Versatile Biocatalytic C(<i>sp</i>³)−H Oxyfunctionalization for the Site‐ Selective and Stereodivergent Synthesis of α‐ and β‐Hydroxy Acids
  作者：Yingle Mao、Weijie Zhang、Zunyun Fu、Yanqiong Liu、Lin Chen、Xin Lian、Dan Zhuo、Jiewei Wu、Mingyue Zheng、Cangsong Liao

  DOI：10.1002/anie.202305250

  日期：2023.8.14

  α-ketoglutarate-dependent aryloxyalkanoate dioxygenases (AADs) are repurposed for applications in biocatalytic oxyfunctionalization. Activity profiling of natural AADs enabled the synthesis of four types of α-and β-hydroxy acids with broad scope, high efficiency, and good selectivity.

  在此，α-酮戊二酸依赖性芳氧基链烷酸双加氧酶（AAD）被重新用于生物催化氧功能化中的应用。天然 AAD 的活性分析使得四种类型的α-和β-羟基酸的合成具有广泛、高效和良好的选择性。
• Catalyst component for the polymerization of alpha-olefins and a process for preparing alpha-olefin polymers with use of same
  申请人：Mitsubishi Chemical Corporation

  公开号：EP0693502A1

  公开（公告）日：1996-01-24

  The present invention provides a catalyst for polymerizing an α-olefin which is capable of producing an α-olefin polymer having a high molecular weight in a high yield under the polymerization conditions including at high temperature, and a process for preparing an α-olefin polymer, which catalyst comprises a Component (A) represented by the formulae (Ia) or (Ib) in which M is Ti, Zr or Hf in combination with a Component (B) which is, for example, an alumoxane.

  本发明提供了一种用于α-烯烃聚合的催化剂，该催化剂能够在包括高温在内的聚合条件下以高产率生产具有高分子量的α-烯烃聚合物，本发明还提供了一种制备α-烯烃聚合物的工艺，该催化剂包括由式(Ia)或(Ib)表示的组分(A)，其中M为Ti、Zr或Hf。 与组分 (B) 结合使用，组分 (B) 例如铝氧烷。