4-苄氧基-5-甲氧基-7-甲氧基甲基-1-萘醛 | 253307-93-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 4-苄氧基-5-甲氧基-7-甲氧基甲基-1-萘醛
• 英文名称: 4-Benzyloxy-5-methoxy-7-methoxymethyl-naphthalene-1-carbaldehyde
• 英文别名: 4-(Benzyloxy)-5-methoxy-7-(methoxymethyl)-1-naphthaldehyde；5-methoxy-7-(methoxymethyl)-4-phenylmethoxynaphthalene-1-carbaldehyde
• CAS: 253307-93-6
• 化学式: C₂₁H₂₀O₄
• 分子量: 336.387
• InChiKey: YUNUEGGUDNXTGS-UHFFFAOYSA-N

物化性质

• 沸点：
  520.2±45.0 °C(Predicted)
• 密度：
  1.188±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-苄氧基-5-甲氧基-7-甲氧基甲基-1-萘醛 在 Stryker's reagent 作用下， 以85%的产率得到(4-Benzyloxy-5-methoxy-7-methoxymethyl-naphthalen-1-yl)-methanol
  参考文献：
  名称：

  Hydrosilylation of aldehydes and ketones catalyzed by [Ph3P(CuH)]6

  摘要：

  Exposure of an aldehyde or ketone to less than or equal to 5 mol% (in copper) of Stryker's reagent [Ph3P(CuH)](6) in the presence of one of several silanes affords the corresponding protected alcohol in high yields. Aldehydes can be cleanly reduced in the presence of ketones. (C) 2001 Elsevier Science B.V, AH rights reserved.

  DOI：

  10.1016/s0022-328x(00)00903-7
• 作为产物：
  描述：

  N-甲氧基-n-甲基甲酰胺 、 8-Benzyloxy-5-bromo-1-methoxy-3-methoxymethyl-naphthalene 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以89%的产率得到4-苄氧基-5-甲氧基-7-甲氧基甲基-1-萘醛
  参考文献：
  名称：

  Formylations of anions with a ‘Weinreb’ formamide: N-methoxy-N-methylformamide

  摘要：

  Treatment of organolithiums, Grignard reagents, or enolates with N-methoxy-N-methylformamide leads to formylated products in good yields without competing secondary processes. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01645-7

文献信息

• Hydrosilylation of aldehydes and ketones catalyzed by [Ph3P(CuH)]6
  作者：Bruce H Lipshutz、Will Chrisman、Kevin Noson

  DOI：10.1016/s0022-328x(00)00903-7

  日期：2001.4

  Exposure of an aldehyde or ketone to less than or equal to 5 mol% (in copper) of Stryker's reagent [Ph3P(CuH)](6) in the presence of one of several silanes affords the corresponding protected alcohol in high yields. Aldehydes can be cleanly reduced in the presence of ketones. (C) 2001 Elsevier Science B.V, AH rights reserved.
• Formylations of anions with a ‘Weinreb’ formamide: N-methoxy-N-methylformamide
  作者：Bruce H. Lipshutz、Steven S. Pfeiffer、Will Chrisman

  DOI：10.1016/s0040-4039(99)01645-7

  日期：1999.11

  Treatment of organolithiums, Grignard reagents, or enolates with N-methoxy-N-methylformamide leads to formylated products in good yields without competing secondary processes. (C) 1999 Elsevier Science Ltd. All rights reserved.