12-propyl-9,9-dimethyl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one | 1219810-72-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 12-propyl-9,9-dimethyl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one
• 英文别名: 9,9-dimethyl-12-propyl-10,12-dihydro-8H-benzo[a]xanthen-11-one
• CAS: 1219810-72-6
• 化学式: C₂₂H₂₄O₂
• 分子量: 320.431
• InChiKey: ADJATMLVDMXFNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5,5-二甲基-1,3-环己二酮 、 正丁醛 、 2-萘酚 在 phosphomolybdic acid supported on schiff base functionalized graphene oxide nanosheets 作用下， 反应 0.5h， 以80%的产率得到12-propyl-9,9-dimethyl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one
  参考文献：
  名称：

  席夫碱官能化氧化石墨烯纳米片上负载的磷钼酸：四氢苯并[a] x吨-1-11-酮的多组分合成中的制备，表征和首次催化应用

  摘要：

  新的席夫碱（SB）官能化的含石墨烯氧化物（GO）纳米片磷反阴离子ħ 2 PMO 12 ø 40 ＆OverBar;（H 2 PMO）成功地被上GO纳米片3-氨丙基三（APTS）的接枝来制备，接着用苯偶酰缩合最后与磷钼酸（H 3 PMo 12 O 40表示为H 3PMo）并使用傅里叶变换红外（FT-IR）光谱，场发射扫描电子显微镜（FESEM），透射电子显微镜（TEM），原子力显微镜（AFM），粒度分布，能量色散X射线（EDX）进行表征）分析，EDX元素映射和电感耦合等离子体发射光谱（ICP-OES）。制备的新型纳米材料，称为GO-SB-H 2 PMo，被证明是β-萘酚，醛和二甲酮的一锅，三组分反应中的一种高效多相催化剂，具有高产率的四氢苯并[ a]在较短的反应时间内生成[xanthene-11]。通过简单的过滤就可以容易地回收催化剂，并且可以循环使用几次，而不会明显降低催化活性。

  DOI：

  10.1002/aoc.4881

文献信息

• New nano-Fe₃O₄-supported Lewis acidic ionic liquid as a highly effective and recyclable catalyst for the preparation of benzoxanthenes and pyrroles under solvent-free sonication
  作者：Hai Truong Nguyen、Ngoc-Phuong Thi Le、Duy-Khiem Nguyen Chau、Phuong Hoang Tran

  DOI：10.1039/c8ra04893b

  日期：——

  magnetic nanomaterial-immobilized Lewis acidic ionic liquid was successfully synthesized by the covalent embedding of 3-(3-(trimethoxysilyl)propyl)-1H-imidazol-3-ium chlorozincate (II) ionic liquid to the surface of Fe3O4 nanoparticles. The material was then characterized by FT-IR, SEM, TEM, TGA, ICP-OES, Raman, and EDS. Its performance as a new-generation Lewis acidic catalyst was also examined on the

  将3-(3-(三甲氧基甲硅烷基)丙基)-1 H-咪唑-3-氯锌酸盐( II )离子液体共价嵌入Fe 3 O表面，成功合成了一种新型磁性纳米材料固定化Lewis酸性离子液体4纳米粒子。然后通过 FT-IR、SEM、TEM、TGA、ICP-OES、拉曼和 EDS 对材料进行表征。其作为新一代路易斯酸性催化剂的性能也在超声介导的苯并氧杂蒽和吡咯合成中进行了检验。完成后，通过外部磁铁简单地回收催化剂以进行多次重复使用，而不会显着降低催化性能。
• Pentafluorophenylammonium Triflate (PFPAT): An Efficient, Practical, and Cost-Effective Catalyst for One-Pot Condensation of β-Naphthol, Aldehydes and Cyclic 1,3-Dicarbonyl Compounds
  作者：Samad Khaksar、Nosratollah Behzadi

  DOI：10.2174/138620712803901153

  日期：2012.11.7

  A pentafluorophenylammonium triflate (PFPAT) catalyst (10 mol%) efficiently promoted one-pot condensation of β-naphthol, aldehydes, and cyclic 1,3-dicarbonyl compounds in good to excellent yield under mild reaction conditions. These catalytic condensations have advantages from the viewpoint of green chemistry. PFPAT organocatalyst is air-stable, cost-effective, easy to handle, and easily removed from

  在轻度的反应条件下，五氟苯基三氟甲磺酸铵（PFPAT）催化剂（10 mol％）有效地促进了β-萘酚，醛和环状1,3-二羰基化合物的一锅缩合。从绿色化学的观点来看，这些催化缩合具有优点。PFPAT有机催化剂是空气稳定的，具有成本效益的，易于处理的，并且易于从反应混合物中除去。
• One-pot Green Procedure for Synthesis of Tetrahydrobenzo[a]xanthene-11-one Catalyzed by Brønsted Ionic Liquids under Solvent-free Conditions
  作者：Masoumeh Zakeri、Majid M. Heravi、Mina Saeedi、Narges Karimi、Hossein A. Oskooie、Niloofar Tavakoli-Hoseini

  DOI：10.1002/cjoc.201180240

  日期：2011.7

  An efficient one‐pot condensation of β‐naphthol, aldehydes and cyclic 1,3‐dicarbonyl compound has been achieved with ionic liquids as catalyst, thus a variety of 8,9,10,12‐tetrahydrobenzo[a]xanthen‐11‐one derivatives were prepared in good yields. The present approach offers several advantages such as shorter reaction times, good yields and mild reaction conditions.

  以离子液体为催化剂，可以实现β-萘酚，醛和环状1,3-二羰基化合物的高效一锅缩合，因此，各种8,9,10,12-四氢苯并[ a ]黄嘌呤-11-酮衍生物的制备得率很高。本方法具有几个优点，例如较短的反应时间，良好的产率和温和的反应条件。
• Formation of benzoxanthenones and benzochromenones via cerium-impregnated-MCM-41 catalyzed, solvent-free, three-component reaction and their biological evaluation as anti-microbial agents
  作者：Adinarayana Murthy Akondi、Mannepalli Lakshmi Kantam、Rajiv Trivedi、Bojja Sreedhar、Sudheer Kumar Buddana、Reddy Shetty Prakasham、Suresh Bhargava

  DOI：10.1016/j.molcata.2014.02.012

  日期：2014.5

  We report here, three-component condensation reaction of naphthols, aldehydes and 1,3-dicarbonyl compounds catalyzed by Ce-MCM-41 under solvent-free conditions. Several advantages can be perceived using this eco-friendly protocol such as, a green and cost-effective procedure with excellent yield, shorter reaction time, simpler work-up, recovery and reusability of solid acid heterogeneous catalyst and tolerance towards a wide range of functional groups. We also report here the anti-microbial activities of the new compounds. Particularly, it was found that the new compounds have shown promising effect on Pseudo monal infections. (C) 2014 Elsevier B.V. All rights reserved.