1-(5-methyl-2-morpholinophenyl)naphthalen-2-ol | 1415461-03-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(5-methyl-2-morpholinophenyl)naphthalen-2-ol
• CAS: 1415461-03-8
• 化学式: C₂₁H₂₁NO₂
• 分子量: 319.403
• InChiKey: ZGJGUQQKCZZTNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.36
• 重原子数：
  24.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  32.7
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  4-甲苯硼酸 在 叔丁基过氧化氢 、 氧气 、 copper(II) acetate monohydrate 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 27.08h， 生成 1-(5-methyl-2-morpholinophenyl)naphthalen-2-ol
  参考文献：
  名称：

  Cerium-containing MCM-41 catalyst for selective oxidative arene cross-dehydrogenative coupling reactions

  摘要：

  Cerium (IV)-mediated intermolecular direct biaryl coupling of aromatic tertiary amines and naphthol via dual C-H bond activation has been reported. The new C-C bond is formed regioselectively ortho to the amino and hydroxyl substituents under oxidative conditions to give substituted bifunctional amino naphthols. We report here the use of Ce-MCM-41 catalyst for the synthesis of these unsymmetrical biaryls via oxidative cross coupling under mild conditions. The catalyst was recovered by simple filtration and reused for several cycles with consistent activity. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.cattod.2012.05.029

文献信息

• Iron‐Catalyzed Oxidative C−C Cross‐Coupling Reaction of Tertiary Anilines with Hydroxyarenes by Using Air as Sole Oxidant
  作者：Alexander Purtsas、Olga Kataeva、Hans‐Joachim Knölker

  DOI：10.1002/chem.201905595

  日期：2020.2.21

  A mild procedure for the oxidative C-C cross-coupling of tertiary anilines with phenols is described which provides the products generally in high yields and with excellent selectivity. The reaction is catalyzed by the hexadecafluorinated iron-phthalocyanine complex FePcF16 in the presence of substoichiometric amounts of methanesulfonic acid and ambient air as sole oxidant.

  描述了用于叔苯胺与酚的氧化CC交叉偶联的温和方法，该方法通常以高收率和优异的选择性提供产物。在亚化学计量量的甲磺酸和环境空气作为唯一氧化剂存在下，通过十六氟化铁-酞菁配合物FePcF16催化该反应。