N-[2,2-Dimethyl-prop-(Z)-ylidene]-N'-methyl-hydrazine | 125424-50-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-[2,2-Dimethyl-prop-(Z)-ylidene]-N'-methyl-hydrazine
• 英文别名: N-(2,2-dimethylpropylideneamino)methanamine
• CAS: 125424-50-2
• 化学式: C₆H₁₄N₂
• 分子量: 114.191
• InChiKey: GMBKZVGMPLOMDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-((E)-2-nitroethenyl)-1,3-benzodioxole 、 N-[2,2-Dimethyl-prop-(Z)-ylidene]-N'-methyl-hydrazine 在 air 作用下， 以 甲醇 为溶剂， 生成 5-benzo[1,3]dioxol-5-yl-3-tert-butyl-1-methyl-1H-pyrazole
  参考文献：
  名称：

  REGIOSELECTIVE SYNTHESIS OF 1,3,5-TRISUBSTITUTED PYRAZOLES BY THE REACTION OF N-MONOSUBSTITUTED HYDRAZONES WITH NITROOLEFINS

  摘要：

  DOI：

  10.15227/orgsyn.085.0179
• 作为产物：
  描述：

  特戊醛 、 甲基肼 以 甲醇 为溶剂， 反应 1.0h， 生成 N-[2,2-Dimethyl-prop-(Z)-ylidene]-N'-methyl-hydrazine
  参考文献：
  名称：

  从腙和β-卤代-β-硝基苯乙烯区域选择性合成4-硝基或4-氯-四取代的吡唑

  摘要：

  我们报告了腙与β-溴-或β-氯-β-硝基苯乙烯的酸催化环加成反应，用于区域选择性合成4-硝基-或4-氯-四取代吡唑。源自常见的 4-卤代-4-硝基吡唑烷中间体，所形成的吡唑产物的特性取决于卤素和硝基取代基的相对离去基团能力。

  DOI：

  10.1002/ejoc.201301294

文献信息

• Hydrolytic Stability of Hydrazones and Oximes
  作者：Jeet Kalia、Ronald T. Raines

  DOI：10.1002/anie.200802651

  日期：2008.9.15

  Hydrazones and oximes are common conjugates, but are labile to hydrolysis. The hydrolytic stability of isostructural hydrazones and an oxime have been determined at pD 5.0–9.0. The hydrolysis of each adduct was catalyzed by acid. Rate constants for oxime hydrolysis were nearly 103-fold lower than those for simple hydrazones; a trialkylhydrazonium ion (formed after condensation) was even more stable than the oxime. The data suggest a general mechanism for conjugate hydrolysis.
• Synthesis of Perhydro-1,3,4-thiadiazin-5-ones and 3-Arylaminothiazolidin-4-ones by the Regioselective Cyclocondensation of 2-Sulfanylalkanoic Acids or Their Silyl Esters with Methyl and Aryl Hydrazones
  作者：Yoo Tanabe、Masaki Nagaosa、Yoshinori Nishii

  DOI：10.3987/com-95-7151

  日期：——

  Perhydro-1,3,4-thiadiazin-5-ones and 3-arylaminothiazolidin-4-ones were prepared by the highly regioselective cyclocondensation of 2-sulfanylalkanoic acids with methyl- and arylhydrazones, respectively. A similar reaction using trimethylsilyl 2-sulfanylalkanoates in the place of the acids proceeded under milder conditions with tetrabutylammonium fluoride catalyst.