1-Adamantylhydrazin | 16782-38-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Adamantylhydrazin
• 英文别名: 1-Hydrazinoadamantan；1-Adamantylhydrazine
• CAS: 16782-38-0
• 化学式: C₁₀H₁₈N₂
• 分子量: 166.266
• InChiKey: KMEKJUFLHHAUKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Adamantylhydrazin 在 盐酸 、 sodium nitrite 作用下， 生成
  参考文献：
  名称：

  一些3-取代的1,2,3,4-伪草三唑-5-酮及其前体和相关化合物的合成和活性。

  摘要：

  DOI：

  10.1021/jm00296a007
• 作为产物：
  描述：

  1-溴金刚烷 在 肼 作用下， 生成 1-Adamantylhydrazin
  参考文献：
  名称：

  一些3-取代的1,2,3,4-伪草三唑-5-酮及其前体和相关化合物的合成和活性。

  摘要：

  DOI：

  10.1021/jm00296a007

文献信息

• A General One-Pot Protocol for Hindered <i>N</i>-Alkyl Azaheterocycles from Tertiary Carboxylic Acids
  作者：Rohan R. Merchant、Simon B. Lang、Tingting Yu、Shuilian Zhao、Zhiqi Qi、Takao Suzuki、Jianming Bao

  DOI：10.1021/acs.orglett.0c01254

  日期：2020.6.5

  Boc deprotection, and heterocycle condensation) to regioselectively prepare hindered C(sp3) substituted pyrazoles and triazoles. The operational simplicity of this sequence and ubiquity of tertiary carboxylic acids allow rapid access to hindered N-alkyl azaheterocycles that will be useful to practitioners of medicinal chemistry and agro-chemistry.

  在这封信中，我们报告了一种通用的一锅策略，该策略利用三个基本步骤（脱羧酰肼化，Boc脱保护和杂环缩合）来选择性地制备受阻C（sp 3）取代的吡唑和三唑。该序列的操作简单性和叔羧酸的普遍性允许快速获得受阻的N-烷基氮杂杂环，这对于药物化学和农业化学的从业者将是有用的。
• Semi-synthetic glycopeptides with antibiotic activity
  申请人：Chu Daniel

  公开号：US20060276623A1

  公开（公告）日：2006-12-07

  Semi-synthetic glycopeptides having antibacterial activity are based on modifications of the eremomycin, A82846B, vancomycin, teicoplanin, and A-40,926 scaffolds, in particular, acylation of the sugar moieties on these scaffolds with certain acyl groups; and/or conversion of an acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides; or having a combination of an alkylation modification of the amino substituent on the amino-substituted sugar moiety on these scaffolds with certain alkyl groups or acylation modification of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain alkyl groups, and conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for the synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

  具有抗菌活性的半合成糖肽基于对eremomycin、A82846B、vancomycin、teicoplanin和A-40,926骨架进行修改，特别是用特定酰基对这些骨架上的糖基进行酰化；和/或将这些骨架上的大环环上的酸基转化为特定的取代酰胺；或者将这些骨架上氨基取代糖基上的氨基取代物进行烷基化修改，使用特定烷基基团或将这些骨架上氨基取代糖基上的氨基取代物进行酰基化修改，以及将这些骨架上的大环环上的酸基转化为特定的取代酰胺的组合。还提供了合成这些化合物的方法，包含这些化合物的药物组合物，以及用于治疗和/或预防疾病，特别是细菌感染的方法。
• Heterodiamondoids
  申请人：CHEVRON USA INC.

  公开号：US20040059145A1

  公开（公告）日：2004-03-25

  This invention is related to heteroatom containing diamondoids (i.e., “heterodiamondoids”) which are compounds having a diamondoid nucleus in which one or more of the diamondoid nucleus carbons has been substitutionally replaced with a noncarbon atom. These heteroatom substituents impart desirable properties to the diamondoid. In addition, the heterodiamondoids are functionalized affording compounds carrying one or more functional groups covalently pendant therefrom. This invention is further related to polymerizable functionalized heterodiamondoids. In a preferred aspect of this invention the diamondoid nuclei are triamantane and higher diamondoid nuclei. In another preferred aspect, the heteroatoms are selected to give rise to diamondoid materials which can serve as n- and p-type materials in electronic devices can serve as optically active materials.

  本发明涉及含杂原子的金刚石烷（即“杂金刚烷”），这些化合物具有金刚烷核，其中一个或多个金刚烷核碳被非碳原子取代。这些杂原子取代基赋予金刚烷理想的性质。此外，这些杂金刚烷被功能化，形成了悬挂着一个或多个官能团的化合物。本发明还涉及可聚合的功能化杂金刚烷。在本发明的首选方面，金刚烷核是三金刚烷和更高的金刚烷核。在另一个首选方面，所选择的杂原子能够产生在电子器件中作为n型和p型材料以及作为光学活性材料的金刚烷材料。
• Methyladamantyl hydrazines, their pharmaceutically acceptable salts and pharmaceutical compositions containing them
  申请人：Teva Pharmaceutical Industries Limited

  公开号：EP0002065A1

  公开（公告）日：1979-05-30

  The invention provides novel 1- or 2-adamantylmethyl hydrazines of the general formulaA In this formula Ad is 1- or 2-adamantyl, R1 and R2 are the same or different and are each hydrogen or a lower unsubstituted or substituted alkyl group of 1-4 carbon atoms; R, and R4 are the same or different and are each hydrogen, an unsubstituted or substituted radical being a lower alkyl group of 1-4 carbon atoms, a lower alkanoic acid radical of 2-4 carbon atoms or a lower alkyl ester thereof, adamantyl, aryl, aralkyl in which the alkyl moiety has 1-4 carbon atoms or an unsubstituted or substituted heterocyclic radical of aromatic character; or R3 and R4 together with the nitrogen atom to which they are attached form a cyclic radical of non-aromatic character. The invention further provides pharmaceutically acceptable acid addition salts of the above compounds. Several methods of preparation of the new compounds are described. The novel compounds according to the invention possess valuable antifungal (human and plant), antiviral, antiprotozoal and antimicrobial properties.

  本发明提供了一般式A的新型1-或2-金刚烷基甲基肼化合物。在该式中，Ad为1-或2-金刚烷基，R1和R2相同或不同，均为氢原子或1-4个碳原子的低级未取代或取代烷基基团；R3和R4相同或不同，均为氢原子、未取代或取代的低级烷基基团、2-4个碳原子的低级烷基酸基团或其低级烷基酯、金刚烷基、芳基、芳基烷基（其中烷基部分有1-4个碳原子）或芳香性质的未取代或取代的杂环基团；或R3和R4与它们所连接的氮原子一起形成非芳香性质的环状基团。本发明还提供了上述化合物的药学上可接受的酸加成盐。描述了几种制备新化合物的方法。根据本发明，新型化合物具有有价值的抗真菌（人类和植物）、抗病毒、抗原虫和抗微生物性质。
• 2-Adamantyl hydrazines and pharmaceutical compositions containing them
  申请人：Teva Pharmaceutical Industries Limited

  公开号：EP0002066A1

  公开（公告）日：1979-05-30

  The invention provides novel 2-adamantyl hydrazine derivatives of the general formula A In this formula R, is hydrogen or a lower alkyl group of 1-4 carbon atoms; R2 and R3 are the same or different and are each hydrogen, an unsubstituted or substituted radical being a lower alkyl of 1-4 carbon atoms, a lower alkanoic acid radical of 2-4 carbon atoms or a lower alkyl ester thereof, adamantyl, aryl, aralkyl, in which the alkyl moiety has from 1-4 carbon atoms or an unsubstituted or substituted heterocyclic radical of aromatic character; or R2 and R3 together with the nitrogen atom to which they are attached form an unsubstituted or substituted non-aromatic cyclic radical. The invention further provides pharmaceutically acceptable acid addition salts of the above compounds. Several methods of preparation of the new compounds are described. The novel compounds according to the invention possess valuable antifungal (human and plant), antiviral, antiprotozoal and antimicrobial properties.

  本发明提供了通式 A 的新型 2-金刚烷基肼衍生物 在该式中，R为氢或1-4个碳原子的低级烷基；R2和R3相同或不同，各自为氢、未取代或取代的1-4个碳原子的低级烷基、2-4个碳原子的低级烷酸基或其低级烷基酯、金刚烷基、芳基、芳烷基（其中烷基具有1-4个碳原子）或未取代或取代的芳香杂环基；或 R2 和 R3 与它们所连接的氮原子一起形成未取代或取代的非芳香环基。 本发明进一步提供了上述化合物的药学上可接受的酸加成盐。 本发明描述了几种新化合物的制备方法。 本发明的新型化合物具有宝贵的抗真菌（人类和植物）、抗病毒、抗原虫和抗微生物特性。