2-[5-(3-Bromophenyl)-3-(2-propan-2-ylphenyl)-3,4-dihydropyrazol-2-yl]-[1,3]thiazolo[4,5-b]quinoxaline | 1061342-95-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-[5-(3-Bromophenyl)-3-(2-propan-2-ylphenyl)-3,4-dihydropyrazol-2-yl]-[1,3]thiazolo[4,5-b]quinoxaline
• CAS: 1061342-95-7
• 化学式: C₂₇H₂₂BrN₅S
• 分子量: 528.475
• InChiKey: XWXRZOYWDXBZST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  82.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,3-二氯喹喔啉 、 5-(3-Bromophenyl)-3-(2-propan-2-ylphenyl)-3,4-dihydropyrazole-2-carbothioamide 以 四氢呋喃 为溶剂， 反应 24.0h， 以22%的产率得到2-[5-(3-Bromophenyl)-3-(2-propan-2-ylphenyl)-3,4-dihydropyrazol-2-yl]-[1,3]thiazolo[4,5-b]quinoxaline
  参考文献：
  名称：

  Syntheses and evaluation of 3-(3-bromo phenyl)-5-phenyl-1-(thiazolo [4,5-b] quinoxaline-2-yl)-2-pyrazoline derivatives

  摘要：

  A variety of 3-(3-bromo phenyl)-5-phenyl-1-(thiazolo [4,5-b] quinoxaline-2-yl)-2-pyrazoline were obtained by the refluxing of 1-N-thiocarbamoyl 3,5-diphenyl-2-pyrazoline with 2,3-dichloroquinoxaline. The chemical structures of the compounds were elucidated by UV, IR, H-1 NMR, and C-13 NMR spectroscopy. The purity of the compounds was confirmed by their elemental analysis. The antiamoebic activity of these compounds was evaluated by microdilution method against HMI:IMSS strain of Entamoeba histolytica and the IC50 values were compared with the standard drug metronidazole. Some of the quinoxaline derivatives showed less IC50 values than metronidazole. To elucidate the toxic effect, MTT assay was performed using kidney epithelial cell line. The results showed that all the compounds are non-toxic. (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.10.026

文献信息

• Syntheses and evaluation of 3-(3-bromo phenyl)-5-phenyl-1-(thiazolo [4,5-b] quinoxaline-2-yl)-2-pyrazoline derivatives
  作者：Asha Budakoti、Abdul R. Bhat、Fareeda Athar、Amir Azam

  DOI：10.1016/j.ejmech.2007.10.026

  日期：2008.8

  A variety of 3-(3-bromo phenyl)-5-phenyl-1-(thiazolo [4,5-b] quinoxaline-2-yl)-2-pyrazoline were obtained by the refluxing of 1-N-thiocarbamoyl 3,5-diphenyl-2-pyrazoline with 2,3-dichloroquinoxaline. The chemical structures of the compounds were elucidated by UV, IR, H-1 NMR, and C-13 NMR spectroscopy. The purity of the compounds was confirmed by their elemental analysis. The antiamoebic activity of these compounds was evaluated by microdilution method against HMI:IMSS strain of Entamoeba histolytica and the IC50 values were compared with the standard drug metronidazole. Some of the quinoxaline derivatives showed less IC50 values than metronidazole. To elucidate the toxic effect, MTT assay was performed using kidney epithelial cell line. The results showed that all the compounds are non-toxic. (c) 2007 Elsevier Masson SAS. All rights reserved.