CNox | 347838-27-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: CNox
• CAS: 347838-27-1
• 化学式: C₃₇H₆₅N₂O₃
• 分子量: 585.935
• InChiKey: YZTFANKNFBBHCB-DCKVPWQYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.3
• 重原子数：
  42
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  42.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  胆固醇甲酰氯 、 4-氨基-TEMPO 在 吡啶 作用下， 以89%的产率得到CNox
  参考文献：
  名称：

  Preparation and Properties of Biphenyl and Cholesterol Derivatives with Nitroxide Radicals

  摘要：

  Series of biphenyl as well as cholesterol derivatives with nitroxide radicals have been prepared to investigate their magnetic/liquid crystalline characters, Weak antiferromagnetic interactions in the low temperature region with no liquid crystalline character have been observed in all cholesterol and several biphenyl derivatives prepared while a cyanobiphenyl derivative with TEMPO substituent have been found to show ferromagnetic interactions in the low temperature region on the one hand and smectic liquid crystalline behavior at elevated temperatures on the other hand.

  DOI：

  10.1080/10587250108023684

文献信息

• Nitroxide-Loaded Hexosomes Provide MRI Contrast in Vivo
  作者：Nicole Bye、Oliver E. Hutt、Tracey M. Hinton、Durga P. Acharya、Lynne J. Waddington、Bradford A. Moffat、David K. Wright、Hong X. Wang、Xavier Mulet、Benjamin W. Muir

  DOI：10.1021/la5007296

  日期：2014.7.29

  to act as T1-enhancing magnetic resonance imaging (MRI) contrast agents, a small library of nitroxide lipids incorporated into cubic-phase lipid nanoparticles (cubosomes). The most effective nitroxide lipid was then formulated into lower-toxicity lipid nanoparticles (hexosomes), and effective MR contrast was observed in the aorta and spleen of live rats in vivo. This new class of lower-toxicity lipid

  这项工作的目的是合成和筛选其作为T 1增强磁共振成像（MRI）造影剂的有效性，该方法是将一个小的一氧化氮脂质文库掺入立方相脂质纳米颗粒（立方体）中。然后将最有效的一氧化氮脂质配制成低毒性的脂质纳米颗粒（六倍体），并在活体大鼠的主动脉和脾脏中观察到有效的MR对比。这类新型的低毒性脂质纳米颗粒可提供更高的弛豫度，其数量级与临床使用的complex络合物相当。与我们先前报道的立方脂质体制剂相比，本文呈现的新的脂质体制剂的毒性显着较低，而弛豫度较高。