methyl 1-{4-[(1-methylpiperidin-4-yl)oxy]benzoyl}-3-({4-[(1-methylpiperidin-4-yl)oxy]bezoyl}amino)-1H-thieno[3,2-c]pyrazole-5-carboxylate | 1055712-01-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: methyl 1-{4-[(1-methylpiperidin-4-yl)oxy]benzoyl}-3-({4-[(1-methylpiperidin-4-yl)oxy]bezoyl}amino)-1H-thieno[3,2-c]pyrazole-5-carboxylate
• 英文别名: Methyl 1-[4-(1-methylpiperidin-4-yl)oxybenzoyl]-3-[[4-(1-methylpiperidin-4-yl)oxybenzoyl]amino]thieno[3,2-c]pyrazole-5-carboxylate
• CAS: 1055712-01-0
• 化学式: C₃₃H₃₇N₅O₆S
• 分子量: 631.753
• InChiKey: MWCBRKGIPCIQQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  45
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  144
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• Heterobicyclic pyrazole derivatives as kinase inhibitors
  申请人：Tonani Roberto

  公开号：US20060160874A1

  公开（公告）日：2006-07-20

  Bicyclo-pyrazoles of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

  公开了如规范中定义的化学式（I）的双环吡唑及其药用盐，其制备方法以及包含它们的药物组合物；本发明的化合物在治疗中可能有用，用于治疗与异常蛋白激酶活性相关的疾病，如癌症。
• [EN] HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS<br/>[FR] DERIVES DE PYRAZOLE HETEROBICYCLIQUES UTILISES COMME INHIBITEURS DE KINASE
  申请人：PHARMACIA ITALIA SPA

  公开号：WO2004007504A1

  公开（公告）日：2004-01-22

  Bicyclo-pyrazoles of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

  公开了规范中定义的化学式(I)的双环吡唑及其药用盐，其制备方法和包含它们的药物组合物；发明中的化合物可能在治疗中对治疗与蛋白激酶活性失调相关的疾病，如癌症，具有用处。
• HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1534716A1

  公开（公告）日：2005-06-01
• US7485661B2
  申请人：——

  公开号：US7485661B2

  公开（公告）日：2009-02-03