maleic acid N-(sec-butyl)isoimide | 27396-40-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: maleic acid N-(sec-butyl)isoimide
• 英文别名: 2(5H)-Furanone, 5-[(1-methylpropyl)imino]-；5-butan-2-yliminofuran-2-one
• CAS: 27396-40-3
• 化学式: C₈H₁₁NO₂
• 分子量: 153.181
• InChiKey: OHKFAGZPMCHTPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-(sec-Butyl)-maleamic acid 在 N-甲基吗啉 、 1-丙基磷酸酐 作用下， 以 乙酸乙酯 为溶剂， 以88%的产率得到maleic acid N-(sec-butyl)isoimide
  参考文献：
  名称：

  Propanephosphonic Acid Anhydride–Mediated Cyclodehydration of Maleic Acid Monoamides

  摘要：

  Propanephosphonic acid anhydride (T3P) has been proposed as a novel reagent for the preparation of maleic acid isoimides from the corresponding monoamides. A series of substituted aromatic and aliphatic isoimides have been prepared in good yields. The main advantage of this synthetic method is the use of environmentally benign, cost-efficient reagents and solvents, which are also safer to handle than the ones employed previously. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.

  DOI：

  10.1080/00397911.2012.727060

文献信息

• Propanephosphonic Acid Anhydride–Mediated Cyclodehydration of Maleic Acid Monoamides
  作者：Igors Klimenkovs、Eduards Bakis、Anda Priksane

  DOI：10.1080/00397911.2012.727060

  日期：2013.10.2

  Propanephosphonic acid anhydride (T3P) has been proposed as a novel reagent for the preparation of maleic acid isoimides from the corresponding monoamides. A series of substituted aromatic and aliphatic isoimides have been prepared in good yields. The main advantage of this synthetic method is the use of environmentally benign, cost-efficient reagents and solvents, which are also safer to handle than the ones employed previously. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.