salarin A | 1005147-97-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: salarin A
• 英文别名: [(E)-4-[3-[(6Z,8E,13Z)-11-acetyl-2-(acetylcarbamoyloxy)-14-methyl-5,10,12-trioxo-4,18-dioxa-11-azabicyclo[15.1.0]octadeca-6,8,13-trien-3-yl]oxiran-2-yl]but-3-enyl] octanoate
• CAS: 1005147-97-6
• 化学式: C₃₅H₄₆N₂O₁₂
• 分子量: 686.756
• InChiKey: KQVPLNKIWHZUGZ-VFVKEPLOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  49
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  188
• 氢给体数：
  1
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  salarin C 在 氧气 作用下， 以 氯仿 为溶剂， 反应 72.0h， 以50%的产率得到salarin A
  参考文献：
  名称：

  Salarin C, a new cytotoxic sponge-derived nitrogenous macrolide

  摘要：

  A novel nitrogenous macrolide, designated salarin C (3), was isolated from the Madagascan sponge Fascaplysinopsis sp. The Structure of the compound was elucidated by interpretation of MS and 1D and 2D NMR spectra. Salarin C is closely related to salarin A and is considered to be the precursor of salarins A and B (1,2). Air oxidation was found to transform 3 to 1. Salarin C was found to inhibit cell proliferation of human leukeamic cell lines UT-7 and K562 and the murine pro-B cell line Ba/F3 at concentrations of 0.0005-0.5 mg/ml. A possible biogenesis is discussed. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.05.038

文献信息

• Salarins And Tulearins, Compositions And Uses Thereof
  申请人：Kashman Yoel

  公开号：US20100311757A1

  公开（公告）日：2010-12-09

  Salarines and Tulearins isolated from Fascaplysinopsis sp. sponge and synthetic derivatives thereof are provided.