| 193674-06-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 193674-06-5
• 化学式: C₃₈H₄₆N₂O₄Sn
• 分子量: 713.504
• InChiKey: KDIHYEMFHIJREN-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  扑湿痛 、 二正丁基氧化锡 以 甲苯 为溶剂， 以80%的产率得到
  参考文献：
  名称：

  ¹H,¹³C,¹¹⁹Sn NMR,^119mSn Mössbauer, Infrared and Mass Spectrometric Studies of Organotin Carboxylates of 2-(2,3-dimethylphenyl)Aminobenzoic Acid and their Effect on Microorganisms.

  摘要：

  The synthesis of a new series of organotin carboxylates of 2-(2,3-dimethylphenyl)aminobenzoic acid is reported. Multinuclear NMR (H-1, C-13, Sn-119) data have been used as a tool for determining their structures in non-coordinating solvents. Solid state structures have been proposed on the basis of IR and Mossbauer parameters. 2D NMR has been used for the assignments of high-spin systems. Screening tests of these compounds showed that they are highly active against bacteria and fungi.

  DOI：

  10.1080/00945719708000234

文献信息

• Enhanced Antioxidant Activity of Di- and Triorganotin Complexes Derived from Mefenamic Acid
  作者：Dhekra Hashim、Tamara Falah、Angham Hadi

  DOI：10.21608/ejchem.2021.82292.4056

  日期：2021.11.14

  Organotin(IV) compounds have gained significant interest in both the chemical and pharmaceutical industry. This research concentrates on synthesis of di and tri-organotin complexes with mefenamic acid and characterized with different techniques such as elemental analysis, FTIR, proton and carbon NMR. The anti-oxidant properties of the complexes were assessed using the 1,1-diphenyl-2-picrylhydrazyl, DPPH and CUPRAC Method . The complexes' scavenging activities were assessed and compared to those of the free drug. The synthesized complexes gives higher antioxidant activity than free drug, also, complex 3 of di methyltin-mefenamic was the highest as compared with the other complexes.

  有机锡(IV) 化合物在化学和制药行业中引起了极大的兴趣。本研究集中于甲芬那酸二有机锡配合物和三有机锡配合物的合成，并通过元素分析、FTIR、质子和碳核磁共振等不同技术进行表征。使用1,1-二苯基-2-三硝基苯肼、DPPH 和 CUPRAC 方法评估复合物的抗氧化性能。评估复合物的清除活性并与游离药物的清除活性进行比较。合成的复合物比游离药物具有更高的抗氧化活性，并且与其他复合物相比，二甲基锡-甲芬那酸的复合物3的抗氧化活性最高。
• Boosted antibacterial efficacy: Di and triorganotin complexes via 2-[(2,3-dimethylphenyl)amino]benzoic acid
  作者：Rana S. Al-Shemary、Hadeer Jasem、Angham G. Hadi、Sadiq J. Baqir

  DOI：10.4314/bcse.v38i3.8

  日期：——

  Using appropriate organotin chloride salts and a ligand called 2-[(2,3-dimethylphenyl) amino] benzoic acid (DMPAB), a condensation procedure produced novel complexes such as triphenyltin, dimethyl, diphenyl, and dibutyl-tin. For difficult identification, a variety of analytical methods were used, including elemental analysis, carbon and proton magnetic resonance, and infrared spectra. The agar ditch method was used to assess the antibacterial effectiveness against Staphylococcus aureus and Escherichia coli. When compared to the molecule generated from the ligand, the complexes showed more inhibitory action. Among the complexes tested, the dimethyltin carboxylate complex showed the strongest antibacterial action against Staphylococcus aureus and Escherichia coli. KEY WORDS: Complexes, Antibacterial properties, Condensation process, Agar Ditch, Staphylococcus aureus and Escherichia coli Bull. Chem. Soc. Ethiop. 2024, 38(3), 647-655.                                                             DOI: https://dx.doi.org/10.4314/bcse.v38i3.8