17-acetoxy-11-oxapregn-4-ene-3,20-dione | 57170-48-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 17-acetoxy-11-oxapregn-4-ene-3,20-dione
• 英文别名: 17α-acetoxy-11-oxaprogesterone；17-Acetoxy-11-oxaprogesterone；[(1S,2S,10S,11S,14R,15R)-14-acetyl-2,15-dimethyl-5-oxo-17-oxatetracyclo[8.7.0.02,7.011,15]heptadec-6-en-14-yl] acetate
• CAS: 57170-48-6
• 化学式: C₂₂H₃₀O₅
• 分子量: 374.477
• InChiKey: ORNAXFAXMIRIQF-WLNPFYQQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  17-acetoxy-11-oxapregn-4-ene-3,20-dione 在 四氯苯醌 作用下， 以 叔丁醇 为溶剂， 反应 7.0h， 以58.3%的产率得到17-acetoxy-11-oxapregna-4,6-diene-3,20-dione
  参考文献：
  名称：

  Antiandrogen. III. Oxapregnane Steroids.

  摘要：

  11-Oxachlormadinone acetate (17-acetoxy-6-chloro-11-oxapregna-4, 6-diene-3, 20-dione) and 2, 11-dioxachlor-madinone acetate (17-acetoxy-6-chloro-2, 11-dioxapregna-4, 6-diene3, 20-dione) were prepared as potential antiandrogenic agnets. The effect of the latter compound on antiandrogenic activity when tested in the castrated rat was shown to be more potent than that of the parent compound, chlormadinone acetate.

  DOI：

  10.1248/cpb.44.746

文献信息

• COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS
  申请人：Miller Freda

  公开号：US20110301105A1

  公开（公告）日：2011-12-08

  We have discovered that p63 inhibition results in increased cellular proliferation. We have also performed a screen for agents capable of increasing cellular proliferation, (e.g., of stem cells such as skin-derived precursors (SKPs)). The invention therefore invention provides compositions, methods, and kits for increasing proliferation of cells, using compounds that decrease p63 expression or activity or using the compounds described herein. The invention also features methods of using these compounds for increasing hair growth, improving skin health, or promoting skin repair in a subject.
• US8748177B2
  申请人：——

  公开号：US8748177B2

  公开（公告）日：2014-06-10
• Antiandrogen. III. Oxapregnane Steroids.
  作者：Shigehiro TAKEGAWA、Naoyuki KOIZUMI、Mamoru MIEDA、Kenyu SHIBATA

  DOI：10.1248/cpb.44.746

  日期：——

  11-Oxachlormadinone acetate (17-acetoxy-6-chloro-11-oxapregna-4, 6-diene-3, 20-dione) and 2, 11-dioxachlor-madinone acetate (17-acetoxy-6-chloro-2, 11-dioxapregna-4, 6-diene3, 20-dione) were prepared as potential antiandrogenic agnets. The effect of the latter compound on antiandrogenic activity when tested in the castrated rat was shown to be more potent than that of the parent compound, chlormadinone acetate.