3,6-bis(diethylamino)-9-(2-(hydrazinecarbonyl)phenyl)xanthylium | 760154-10-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3,6-bis(diethylamino)-9-(2-(hydrazinecarbonyl)phenyl)xanthylium
• 英文别名: rhodamine B hydrazide
• CAS: 760154-10-7
• 化学式: C₂₈H₃₃N₄O₂
• 分子量: 457.596
• InChiKey: DJDMGKHWDIAFFQ-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  5.83
• 重原子数：
  34.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  72.9
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  3,6-bis(diethylamino)-9-(2-(hydrazinecarbonyl)phenyl)xanthylium 在 mercury (II) perchlorate trihydrate 、 水 作用下， 以 乙醇 为溶剂， 生成 罗丹明B
  参考文献：
  名称：

  Rhodamine–pyrene conjugated chemosensors for ratiometric detection of Hg2+ ions: Different sensing behavior between a spirolactone and a spirothiolactone

  摘要：

  Two novel rhodamine-pyrene conjugated chemosensors were successfully designed and synthesized, which exhibited high affinity to Hg2+ ions. As ratiometric chemosensors, each displayed highly selective and sensitive colorimetric and fluorogenic dual-responses toward Hg2+. The comparison of two chemosensors indicated that the spirothiolactone containing sensor was superior to the spirolactone analog in sensing behavior when detecting Hg2+, presumably due to the thiophilic nature of mercury and the different sensing mechanisms in operation. Upon interaction with Hg2+, the spirothiolactone showed a 1:1 stoichiometry for the Hg2+ complex, accompanied with a weakened fluorescence resonance energy transfer (FRET) behavior. However, the spirolactone was hydrolyzed and consequently induced the monomer-excimer switch of the resulted pyrene in the presence of Hg2+ ions. Crown Copyright (c) 2013 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2013.02.019
• 作为产物：
  描述：

  罗丹明B 在 水 、 copper dichloride 、 肼 作用下， 以 异丙醇 、 乙腈 为溶剂， 反应 3.0h， 生成 3,6-bis(diethylamino)-9-(2-(hydrazinecarbonyl)phenyl)xanthylium
  参考文献：
  名称：

  Highly sensitive and selective turn-on fluorescent probes for Cu²⁺ based on rhodamine B

  摘要：

  一种基于新罗丹明B的荧光探针RL针对Cu²⁺进行了设计、合成和表征。

  DOI：

  10.1039/c5tb00423c

文献信息

• New fluorescent macrolide derivatives for studying interactions of antibiotics and their analogs with the ribosomal exit tunnel
  作者：A. G. Tereshchenkov、A. V. Shishkina、V. V. Karpenko、V. A. Chertkov、A. L. Konevega、P. S. Kasatsky、A. A. Bogdanov、N. V. Sumbatyan

  DOI：10.1134/s0006297916100138

  日期：2016.10

  substance. With the synthesized fluorescent tylosin derivatives, the dissociation constants for ribosome complexes with several known antibiotics and macrolide analogs previously obtained were determined. It was found that the fluorescent tylosin derivatives containing BODIPY FL and NBD groups could be used to screen the binding of novel antibiotics to bacterial ribosomes in the macrolide-binding site

  合成了大环内酯类抗生素的新型荧光衍生物，该衍生物与带有罗丹明，荧光素，Alexa Fluor 488，BODIPY FL和硝基苯并恶二唑（NBD）残基的泰乐菌素有关。这些化合物与70S大肠杆菌核糖体的复合物的形成通过在恒定浓度的荧光物质下根据核糖体量测量荧光偏振来研究。用合成的荧光泰乐菌素衍生物，测定核糖体与几种先前已知的抗生素和大环内酯类似物的复合物的解离常数。发现含有BODIPY FL和NBD基团的荧光泰乐菌素衍生物可用于在大环内酯结合位点筛选新型抗生素与细菌核糖体的结合。