2-(3-Hydroxy-5-oxo-4-pentylfuran-2-ylidene)acetic acid | 66521-20-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 2-(3-Hydroxy-5-oxo-4-pentylfuran-2-ylidene)acetic acid
• CAS: 66521-20-8；93796-54-4
• 化学式: C₁₁H₁₄O₅
• 分子量: 226.229
• InChiKey: IZLIRBKYKYMRPY-UHFFFAOYSA-N

物化性质

• 沸点：
  338.6±42.0 °C(Predicted)
• 密度：
  1.401±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• MYCOBACTERIUM MEMBRANE PROTEASE AS A TARGET FOR INHIBITORS OF INTRABACTERIAL pH HOMEOSTASIS
  申请人：Nathan Carl

  公开号：US20110190234A1

  公开（公告）日：2011-08-04

  The present invention is directed to methods and compounds for inhibiting bacterial growth and treating a bacterial infection in a subject. These methods involve providing an inhibitor of intrabacterial pH homeostasis, including inhibitors of the Mycobacterium tuberculosis Rv3671c gene encoded membrane protease. Methods for identifying novel compounds that disrupt intrabacterial pH homeostasis and their use for inhibiting bacterial growth and treating a bacterial infection in a subject are also disclosed.
• US8951992B2
  申请人：——

  公开号：US8951992B2

  公开（公告）日：2015-02-10
• [EN] MYCOBACTERIUM TUBERCULOSIS RV3671C GENE ENCODED MEMBRANE PROTEASE AS A TARGET FOR INHIBITORS OF INTRABACTERIAL PH HOMEOSTASIS AND ACID RESISTANCE<br/>[FR] PROTÉASE DE MEMBRANE ENCODÉE DE GÈNE RV3671C DE MYCOBACTERIUM TUBERCULOSIS EN TANT QUE CIBLE POUR INHIBITEURS D'HOMÉOSTASIE DE PH INTRA-BACTÉRIEN ET DE RÉSISTANCE À UN ACIDE
  申请人：UNIV CORNELL

  公开号：WO2010009456A1

  公开（公告）日：2010-01-21

  The present invention is directed to methods and compounds for inhibiting bacterial growth and treating a bacterial infection in a subject. These methods involve providing an inhibitor of intrabacterial pH homeostasis, including inhibitors of the Mycobacterium tuberculosis Rv3671c gene encoded membrane protease. Methods for identifying novel compounds that disrupt intrabacterial pH homeostasis and their use for inhibiting bacterial growth and treating a bacterial infection in a subject are also disclosed.