2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(1-methoxypropan-2-yl)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(1-methoxypropan-2-yl)acetamide
• 英文别名: 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(1-methoxypropan-2-yl)acetamide
• 化学式: C₁₃H₁₉N₅O₄
• 分子量: 309.32
• InChiKey: BRKIDXKLEQGPIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  96.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] COMPOSITIONS AND METHODS OF TREATMENT FOR TUMORS IN THE NERVOUS SYSTEM<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT DE TUMEURS DANS LE SYSTÈME NERVEUX
  申请人：UNIV GEORGETOWN

  公开号：WO2011156632A2

  公开（公告）日：2011-12-15

  The invention provides compounds, compositions and methods for preventing and treating tumors of the nervous system, by means of compounds that inhibit or modulate p75 neurotrophic receptors. Compounds of the invention have structures of the form G-H-I, wherein G is a small ring system reminiscent of redox-mediating moieties in metabolism, H is a linker of up to 8 atoms in length, and I is a simple end group such as a lower alkyl or small heteroaryl or heterocyclic ring system.