4,4-dimethylchroman-6-ol | 111580-18-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 4,4-dimethylchroman-6-ol
• 英文别名: 2,3-Dihydro-4,4-dimethyl-6-hydroxy-4H-1-benzopyran；4,4-dimethyl-2,3-dihydrochromen-6-ol
• CAS: 111580-18-8
• 化学式: C₁₁H₁₄O₂
• 分子量: 178.231
• InChiKey: NFPNFWUYFNHEFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,3-二甲基丙烯酸甲酯 在 对甲苯磺酸 硫酸 、 对苯二酚 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 以70%的产率得到4,4-dimethylchroman-6-ol
  参考文献：
  名称：

  Aromatic urea derivatives and their use as herbicide

  摘要：

  这项发明涉及公式[I]的新化合物，其生产过程以及它们作为除草剂的用途。其中A代表键##STR2##其中X是氢原子、氯原子、硝基团或三氟甲基基团；B代表氢原子、甲基基团或甲氧基基团；Ar代表从##STR3##中选择的一个成员，其中R.sup.1到R.sup.38如下所定义。

  公开号：

  US04838924A1

文献信息

• 6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR
  申请人：BAO JIANMING

  公开号：US20170183342A1

  公开（公告）日：2017-06-29

  The present invention is directed to 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-5-one compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

  本发明涉及6,7-二氢-5H-吡咯[3,4-b]吡啶-5-酮化合物，这些化合物是M4毒蕈碱乙酰胆碱受体的变构调节剂。本发明还涉及在本申请中描述的化合物在潜在治疗或预防神经和精神障碍和疾病中的应用，其中涉及M4毒蕈碱乙酰胆碱受体。本发明还涉及包含这些化合物的组合物。本发明还涉及这些组合物在潜在预防或治疗涉及M4毒蕈碱乙酰胆碱受体的疾病的应用。
• [EN] HYDANTOIN MODULATORS OF KV3 CHANNELS<br/>[FR] HYDANTOÏNES UTILISÉES EN TANT QUE MODULATEURS DE CANAUX KV3
  申请人：AUTIFONY THERAPEUTICS LTD

  公开号：WO2017103604A1

  公开（公告）日：2017-06-22

  The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.

  该发明提供了式(I)的化合物：所述化合物是Kv3通道的抑制剂，可用于预防或治疗相关疾病。
• TRIAZOLES AS KV3 INHIBITORS
  申请人：AUTIFONY THERAPEUTICS LIMITED

  公开号：US20150111910A1

  公开（公告）日：2015-04-23

  Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.

  公式（I）的化合物可用于调节Kv3.1，Kv.3.2和Kv3.3通道，并在相关疾病的治疗或预防中具有用途。
• 6,7-dihydro-5H-pyrrolo[3,4-B]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor
  申请人：Bao Jianming

  公开号：US10329289B2

  公开（公告）日：2019-06-25

  The present invention is directed to 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-5-one compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

  本发明涉及 6,7-二氢-5H-吡咯并[3,4-b]吡啶-5-酮化合物，这些化合物是 M4 肌 肉碱乙酰胆碱受体的异构调节剂。本发明还涉及本文所述化合物在潜在治疗或预防涉及 M4 肌卡因乙酰胆碱受体的神经和精神障碍及疾病中的用途。本发明还涉及包含这些化合物的组合物。本发明还涉及这些组合物在潜在预防或治疗涉及 M4 蕈样乙酰胆碱受体的此类疾病中的用途。
• 6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor
  申请人：Merck Sharp & Dohme Corp.

  公开号：US10351564B2

  公开（公告）日：2019-07-16

  The present invention is directed to 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-5-one compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

  本发明涉及 6,7-二氢-5H-吡咯并[3,4-b]吡啶-5-酮化合物，这些化合物是 M4 肌 肉碱乙酰胆碱受体的异构调节剂。本发明还涉及本文所述化合物在潜在治疗或预防涉及 M4 肌卡因乙酰胆碱受体的神经和精神障碍及疾病中的用途。本发明还涉及包含这些化合物的组合物。本发明还涉及这些组合物在潜在预防或治疗涉及 M4 蕈样乙酰胆碱受体的此类疾病中的用途。