2-(2-hydroxyethyl)-4-hydroxy-1,3-dioxane | 36986-33-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 2-(2-hydroxyethyl)-4-hydroxy-1,3-dioxane
• 英文别名: 3-hydroxypropionaldehyde dimer；2-(2-hydroxy-ethyl)-[1,3]dioxan-4-ol；2-(2-Hydroxy-aethyl)-[1,3]dioxan-4-ol；2-(2-hydroxyethyl)-1,3-dioxan-4-ol
• CAS: 36986-33-1
• 化学式: C₆H₁₂O₄
• 分子量: 148.159
• InChiKey: CMFSVRNUSJXFLF-UHFFFAOYSA-N

物化性质

• 沸点：
  297.2±30.0 °C(Predicted)
• 密度：
  1.228±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2-hydroxyethyl)-4-hydroxy-1,3-dioxane 在 吡啶 、 乙酸酐 作用下， 生成 4-acetoxy-2-(2-acetoxy-ethyl)-[1,3]dioxane
  参考文献：
  名称：

  96.酸催化的丙烯醛水合。β-羟基丙醛反应动力学及分离

  摘要：

  DOI：

  10.1039/jr9500000490
• 作为产物：
  描述：

  罗氏菌素 生成 2-(2-hydroxyethyl)-4-hydroxy-1,3-dioxane
  参考文献：
  名称：

  96.酸催化的丙烯醛水合。β-羟基丙醛反应动力学及分离

  摘要：

  DOI：

  10.1039/jr9500000490

文献信息

• HETEROGENEOUS PROMOTION OF OXIRANE HYDROFORMYLATION
  申请人：Mullin Stephen Blake

  公开号：US20090163742A1

  公开（公告）日：2009-06-25

  A process for making betahydroxyaldehydes such as 3-hydroxypropanal which comprises intimately contacting (a) an oxirane, (b) carbon monoxide, (c) a reducing agent such as hydrogen, (d) from about 0.01 to about 1 weight percent, basis cobalt metal, of a cobalt hydroformylation catalyst which is optionally complexed with a tertiary phosphine ligand, and (e) a heterogeneous, preferably solid, metal promoter used at a molar ratio of 0.05, preferably 0.15, to 100 moles of heterogeneous metal relative to the moles of soluble cobalt hydroformylation catalyst.

  制备β-羟基醛的方法，例如3-羟基丙醛，包括密切接触(a)环氧烷，(b)一氧化碳，(c)还原剂，例如氢气，(d)约0.01至约1重量％，以钴金属为基础，可选择与三级膦配体形成络合物的钴羟甲酰化催化剂，以及(e)使用的非均相，优选为固体的金属促进剂，其用量为相对于可溶性钴羟甲酰化催化剂的摩尔数，0.05，优选为0.15，到100摩尔。
• Process for making 1,3-diols from epoxides
  申请人：HOECHST CELANESE CORPORATION

  公开号：EP0343944A2

  公开（公告）日：1989-11-29

  A process for manufacturing 1,3-glycols is disclosed. The process comprises reacting an epoxide with synthesis gas in the presence of rhodium in the presence of an alkali metal compound.

  本发明公开了一种制造 1,3-乙二醇的工艺。该工艺包括在铑和碱金属化合物存在的情况下使环氧化物与合成气反应。
• Catalysts for producing 1,3-diols and/or 3-hydroxy-aldehydes, and processes for making and using same
  申请人：UNION CARBIDE CHEMICALS AND PLASTICS COMPANY, INC.

  公开号：EP0455257A2

  公开（公告）日：1991-11-06

  A process for producing a 1,3-diol, e.g., 1,3-propanediol or a 3-hydroxyaldehyde is disclosed which comprises contacting a combination of an epoxide carbon monoxide and hydrogen in the present of a rhodium-containing catalyst effective to promote the hydroformylation of the epoxide at conditions effective to form at least one of a 1,3-diol and a 3-hydroxyaldehyde, the contacting occurring in the substantial absence of a promoting amount of alkali metal ions, and at least a portion of the rhodium-containing catalyst being formed substantially without incorporation of the epoxide. A process for producing such rhodium-containing compositions is also disclosed.

  本发明公开了一种生产 1,3-二醇（如 1,3-丙二醇或 3-羟基醛）的工艺、本发明公开了一种生产 1,3-二醇（例如 1,3-丙二醇）或 3-羟基醛的工艺，该工艺包括在有效促进环氧化物氢化的含铑催化剂存在的条件下，使环氧化物一氧化碳和氢的组合接触，以形成 1、3-二醇和 3-羟基醛中的至少一种，该接触是在基本上没有碱金属离子促进量的情况下进行的，并且至少有一部分含铑催化剂是在基本上没有加入环氧化物的情况下形成的。还公开了生产这种含铑组合物的工艺。
• Catalysts and processes useful in producing 1,3-diols and/or 3-hydroxyaldehydes
  申请人：UNION CARBIDE CHEMICALS AND PLASTICS COMPANY INC. (a New York corporation)

  公开号：EP0455261A1

  公开（公告）日：1991-11-06

  A process for producing a 1,3-diol, e.g., 1,3-propanediol, and/or a 3-hydroxyaldehyde, e.g., 3-hydroxypropionaldehyde is disclosed which comprises contacting a combination of an epoxide, carbon monoxide and hydrogen in the presence of a rhodium-containing catalyst composition effective to promote the hydroformylation of the epoxide at conditions effective to form at least one of a 1,3-diol and a 3-hydroxyaldehyde. The rhodium-containing catalyst composition comprises an anionic rhodium-containing complex. A promoter component is preferably provided to enhance at least one of the rate and selectivity of the epoxide hydroformylation reaction. Rhodium-containing compositions and a processes for producing rhodium-containing compositions are also disclosed.

  本发明公开了一种生产1,3-二醇（如1,3-丙二醇）和/或3-羟基醛（如3-羟基丙醛）的工艺，该工艺包括在含铑催化剂组合物存在下，使环氧化物、一氧化碳和氢的组合物接触，该催化剂组合物能有效地促进环氧化物在有效条件下的氢甲酰化，以形成1,3-二醇和3-羟基醛中的至少一种。含铑催化剂组合物包括阴离子含铑络合物。最好提供一种促进剂成分，以提高环氧化物加氢甲酰化反应的速率和选择性中的至少一种。还公开了含铑组合物和生产含铑组合物的工艺。
• Food composition containing reuterin
  申请人：BIOGAIA AB

  公开号：EP0698347A2

  公开（公告）日：1996-02-28

  The antibiotic reuterin is obtained by cultivating strains of Lactobacillus reuteri under controlled conditions. Reuterin has inhibitory activity against Gram positive and Gram negative bacteria, against the yeast, Saccharomyces cerevisiae, and against the protozoan, Trypanosoma cruzi. Reuterin producing strains are identified by growth inhibition of suspectible microorganisms in the presence of glycerol or glyceraldehyde.

  抗生素芦丁是通过在受控条件下培养芦特氏乳杆菌菌株获得的。芦丁素对革兰氏阳性和革兰氏阴性细菌、酵母菌和原生动物克氏锥虫具有抑制活性。在有甘油或甘油醛存在的情况下，通过抑制可疑微生物的生长，可以鉴定出产生芦丁素的菌株。