2-Amino-8-morpholino-1H-purin-6(9H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-Amino-8-morpholino-1H-purin-6(9H)-one
• 英文别名: 2-amino-8-morpholin-4-yl-1,7-dihydropurin-6-one
• 化学式: C₉H₁₂N₆O₂
• 分子量: 236.23
• InChiKey: NYDOHXMVJHDKNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  109
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• SYNTHESIS OF MORPHOLINO OLIGOMERS USING DOUBLY PROTECTED GUANINE MORPHOLINO SUBUNITS
  申请人：REEVES MATTHEW DALE

  公开号：US20090131624A1

  公开（公告）日：2009-05-21

  Morpholino compounds are provided having the structure: where R 1 is selected from the group consisting of lower alkyl, di(lower alkyl)amino, and phenyl; R 2 is selected from the group consisting of lower alkyl, monocyclic arylmethyl, and monocyclic (aryloxy)methyl; R 3 is selected from the group consisting of triarylmethyl and hydrogen; and Y is selected from the group consisting of: a protected or unprotected hydroxyl or amino group; a chlorophosphoramidate group; and a phosphorodiamidate linkage to the ring nitrogen of a further morpholino compound or a morpholino oligomer. Such compounds include doubly protected morpholino guanine (MoG) monomers. Also described is their use in synthesis of morpholino oligomers.

  Morpholino化合物具有以下结构： 其中 R1选自由较低烷基、二(较低烷基)氨基和苯基组成的群体； R2选自由较低烷基、单环芳基甲基和单环(芳氧基)甲基组成的群体； R3选自由三芳基甲基和氢原子组成的群体；以及 Y选自由受保护或未受保护的羟基或氨基团；氯磷酰胺基团；以及与另一种morpholino化合物或morpholino寡聚体的环氮原子形成磷酰二胺酸酯键的群体。这类化合物包括双保护的morpholino鸟嘌呤（MoG）单体。还描述了它们在morpholino寡聚体合成中的用途。
• METHOD OF SYNTHESIS OF MORPHOLINO OLIGOMERS
  申请人：AVI BioPharma, Inc.

  公开号：EP2207779A1

  公开（公告）日：2010-07-21
• US8076476B2
  申请人：——

  公开号：US8076476B2

  公开（公告）日：2011-12-13
• [EN] METHOD OF SYNTHESIS OF MORPHOLINO OLIGOMERS<br/>[FR] PROCÉDÉ DE SYNTHÈSE D'OLIGOMÈRES MORPHOLINO
  申请人：AVI BIOPHARMA INC

  公开号：WO2009064471A1

  公开（公告）日：2009-05-22

  Morpholino compounds are provided having the structure (I): where R1 is selected from the group consisting of lower alkyl, di(lower alkyl)amino, and phenyl; R2 is selected from the group consisting of lower alkyl, monocyclic arylmethyl, and monocyclic (aryloxy)methyl; R3 is selected from the group consisting of triarylmethyl and hydrogen; and Y is selected from the group consisting of: a protected or unprotected hydroxyl or amino group; a chlorophosphoramidate group; and a phosphorodiamidate linkage to the ring nitrogen of a further morpholino compound or a morpholino oligomer. Such compounds include doubly protected morpholino guanine (MoG) monomers. Also described is their use in synthesis of morpholino oligomers, and further improved procedures for synthesis of morpholino oligomers, pertaining to deprotection of the protected morpholino ring nitrogen at each monomer coupling step.