6-Methylideneandrosta-1,4-diene-3,17-dione

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 6-Methylideneandrosta-1,4-diene-3,17-dione
• 英文别名: 10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione
• 化学式: C₂₀H₂₄O₂
• 分子量: 296.4
• InChiKey: BFYIZQONLCFLEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Bifunctional AKR1C3 Inhibitors/Androgen Receptor Modulators and Methods of Use Thereof
  申请人：The Trustees of The University of Pennsylvania

  公开号：US20140107085A1

  公开（公告）日：2014-04-17

  The invention includes compositions comprising selective AKR1C3 inhibitors. The invention also includes compositions comprising bifunctional AKR1C3 inhibitors and selective androgen receptor modulators. The invention further includes methods of treatment using the compositions of the invention.

  该发明包括含有选择性AKR1C3抑制剂的组合物。该发明还包括含有双功能AKR1C3抑制剂和选择性雄激素受体调节剂的组合物。该发明还包括使用该发明的组合物进行治疗的方法。
• New therapeutic approaches for treating Charcot-Marie-Tooth disease
  申请人：Pharnext

  公开号：EP2065038A1

  公开（公告）日：2009-06-03

  The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders. More particularly, the invention relates to combined therapies for treating said disease by decreasing PMP22 expression in a subject.

  本发明涉及治疗夏科-玛丽-牙病及相关疾病的组合物和方法。更具体地说，本发明涉及通过降低受试者体内 PMP22 表达来治疗上述疾病的联合疗法。
• Bifunctional AKR1C3 inhibitors/androgen receptor modulators and methods of use thereof
  申请人：The Trustees of the University of Pennsylvania

  公开号：US10071953B2

  公开（公告）日：2018-09-11

  The invention includes compositions comprising selective AKR1C3 inhibitors. The invention also includes compositions comprising bifunctional AKR1C3 inhibitors and selective androgen receptor modulators. The invention further includes methods of treatment using the compositions of the invention.

  本发明包括由选择性 AKR1C3 抑制剂组成的组合物。本发明还包括包含双功能 AKR1C3 抑制剂和选择性雄激素受体调节剂的组合物。本发明还包括使用本发明组合物的治疗方法。
• PHARMACEUTICAL COMPOSITIONS OF AN SRC KINASE INHIBITOR AND AN AROMATASE INHIBITOR
  申请人：Zacharchuk Charles Michael

  公开号：US20100069340A1

  公开（公告）日：2010-03-18

  This invention is directed to a pharmaceutical composition comprising an Src kinase inhibitor and an aromatase inhibitor, and to the use of a combination of an Src kinase inhibitor and an aromatase inhibitor in treating abnormal cell proliferation and abnormal angiogenesis associated with cancer, including breast cancer.
• US9271961B2
  申请人：——

  公开号：US9271961B2

  公开（公告）日：2016-03-01