Finasteride | 1212235-84-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Finasteride
• 英文别名: N-tert-butyl-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide；N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
• CAS: 1212235-84-1
• 化学式: C₂₃H₃₆N₂O₂
• mdl: MFCD08064825
• 分子量: 372.551
• InChiKey: DBEPLOCGEIEOCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  亚硝酸特丁酯 、 9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carbonitrile 在 水 作用下， 以 二氯甲烷 为溶剂， 以84 %的产率得到Finasteride
  参考文献：
  名称：

  使用亚硝酸叔丁酯 (TBN) 作为实用碳源，在无热、无金属和无酸条件下轻松制备 N-叔丁基酰胺

  摘要：

  亚硝酸叔丁酯 (TBN) 是一种无毒物质，经常用作氮、氧或一氧化氮 (NO) 的来源，但不能用作化学转化中的碳源。在这里，据我们所知，我们首次引入 TBN 作为碳源（叔丁基），用于在非常温和的条件下从腈和水中合成高价值的N-叔丁基酰胺。

  DOI：

  10.1039/d3cc01168b

文献信息

• Non-Androgen Dependent Roles for Androgen Receptor and Non-Androgen Related Inhibitors of Androgen Receptor
  申请人：Chang Chawnshang

  公开号：US20080050387A1

  公开（公告）日：2008-02-28

  Disclosed are compositions and methods for modulating AR activity, such as non-androgen dependent AR activity. Also disclosed are compositions and methods for diagnosing beast cancer and for inhibiting breast cancer growth. In addition, disclosed are methods for identifying molecules that inhibit AR in non-androgen dependent ways.
• Androgen Receptor Related Methods for Treating Bladder Cancer
  申请人：Chang Chawnshang

  公开号：US20090282496A1

  公开（公告）日：2009-11-12

  Disclosed are compositions and methods for treating bladder cancer.
• US7501515B2
  申请人：——

  公开号：US7501515B2

  公开（公告）日：2009-03-10
• [EN] TOPICAL FORMULATIONS COMPRISING DUTASTERIDE FOR TREATING DERMATOLOGICAL DISORDERS INCLUDING MALE PATTERN BALDNESS<br/>[FR] FORMULATIONS TOPIQUES COMPRENANT DU DUTASTÉRIDE POUR LE TRAITEMENT DE TROUBLES DERMATOLOGIQUES COMPRENANT LA CALVITIE MASCULINE
  申请人：XYON HEALTH INC

  公开号：WO2021225987A1

  公开（公告）日：2021-11-11

  The present disclosure provides a liposomal topical formulation comprising dutasteride having barrier-forming siliconic components, methods for making the same, and methods for using the same in the treatment of dermatological diseases and conditions, including male pattern baldness.
• Facile preparation of <i>N-tert</i>-butyl amides under heat-, metal- and acid-free conditions by using <i>tert</i>-butyl nitrite (TBN) as a practical carbon source
  作者：Palani Natarajan、Onder Metin

  DOI：10.1039/d3cc01168b

  日期：——

  tert-Butyl nitrite (TBN) is a nontoxic substance that has frequently been used as a source of nitrogen, oxygen, or nitric oxide (NO), but not as a carbon source in chemical transformations. Here, for the first time to the best of our knowledge, we introduced TBN as a source of carbon (tert-butyl group) for the synthesis of highly valuable N-tert-butyl amides from nitriles and water under very mild conditions

  亚硝酸叔丁酯 (TBN) 是一种无毒物质，经常用作氮、氧或一氧化氮 (NO) 的来源，但不能用作化学转化中的碳源。在这里，据我们所知，我们首次引入 TBN 作为碳源（叔丁基），用于在非常温和的条件下从腈和水中合成高价值的N-叔丁基酰胺。