2,6-dibromo-3,5-dihydroxyphenylacetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2,6-dibromo-3,5-dihydroxyphenylacetic acid
• 英文别名: 2-(2,6-dibromo-3,5-dihydroxyphenyl)acetic acid
• 化学式: C₈H₆Br₂O₄
• 分子量: 325.941
• InChiKey: DLTYARYHLVOXJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,6-Dibrom-3,5-dimethoxy-phenylessigsaeure 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以80 %的产率得到2,6-dibromo-3,5-dihydroxyphenylacetic acid
  参考文献：
  名称：

  Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products

  摘要：

  天然产物2-(2,3-二溴-4,5-二羟基苯基)乙酸（1）和2-(2,6-二溴-3,5-二羟基苯基)乙酸（2）以及它们的衍生物25和26的合成是通过相应的四个溴化苄的取代、水解和脱甲基反应进行的。首次通过几种出色的生物分析方法评估了苄基酸衍生的溴酚的抗氧化潜力。除此之外，我们还评估了使用DPPH·、ABTS·+清除活性、铁（Fe3+）和铜（Cu2+）离子以及Fe3+-TPTZ还原能力等方法研究的抗氧化效果。苄基酸衍生的溴酚被证明是有效的DPPH·和ABTS·+清除剂。将溴酚衍生物1、2和17-28的潜在抗氧化活性与包括BHA、BHT、α-生育酚和Trolox（维生素E的水溶性类似物）在内的标准抗氧化剂进行了比较。我们预计这项创新工作将指导未来探索食品、药物和工业应用中抗氧化特性的研究。

  DOI：

  10.55730/1300-0527.3447

文献信息

• METHOD FOR PREPARING LADDERANES
  申请人：MacGillivray Leonard R.

  公开号：US20090088572A1

  公开（公告）日：2009-04-02

  Ditopic molecules in the form of linear reaction templates have been used to construct ladder-like hydrocarbons known as [n]-ladderanes (n=3,5). The templates assemble and position reactant molecules in the solid state by way of hydrogen bonds for [2+2] photodimerization. The products, which are based on recently identified naturally occurring frameworks, form stereospecifically, in gram quantities, and in quantitative yield. The control of reactivity achieved using linear templates provides a basis for the development of molecular tools, termed assemblers, that could be used to manufacture, with atomic-level precision, a wide range of products (e.g. molecular nanostructures) with unique properties.
• US7524966B2
  申请人：——

  公开号：US7524966B2

  公开（公告）日：2009-04-28
• [EN] METHOD FOR PREPARING LADDERANES<br/>[FR] PROCEDE D'ELABORATION DE LADDERANES
  申请人：UNIV IOWA RES FOUND

  公开号：WO2005035473A2

  公开（公告）日：2005-04-21

  Ditopic molecules in the form of linear reaction templates are used to construct ladder-like hydrocarbons known as [n]-ladderanes (n = 3,5). The templates assemble and position reactant molecules in the solid state for [2+2] photodimerization. The products, which are based on recently identified naturally occurring frameworks, form stereospecifically, in gram quantities, and in quantitative yield. The control of reactivity achieved using linear templates provides a basis for the development of molecular tools, termed assemblers, that could be used to manufacture, with atomic-level precision, a wide range of products (e.g. molecular nanostructures) with unique properties.