7-hydroxy-2-trifluoromethyl-3-(1-methyl-2-benzimidazolyl)-6-ethylchromone | 210639-84-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 7-hydroxy-2-trifluoromethyl-3-(1-methyl-2-benzimidazolyl)-6-ethylchromone
• 英文别名: JFD02282；EEEO6；6-ethyl-7-hydroxy-3-(1-methyl-1H-benzimidazol-2-yl)-2-(trifluoromethyl)-4H-chromen-4-one；6-ethyl-7-hydroxy-3-(1-methylbenzimidazol-2-yl)-2-(trifluoromethyl)chromen-4-one
• CAS: 210639-84-2
• 化学式: C₂₀H₁₅F₃N₂O₃
• mdl: MFCD00595581
• 分子量: 388.346
• InChiKey: DSAJLEKUBMUVMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 7-hydroxy-2-trifluoromethyl-3-(1-methyl-2-benzimidazolyl)-6-ethylchromone 以 溶剂黄146 为溶剂， 以92%的产率得到7-acetoxy-3-(1-methyl-2-benzimidazolyl)-2-trifluoromethyl-6-ethylchromone
  参考文献：
  名称：

  异黄酮异类似物的化学。20.异黄酮的苯并咪唑类似物

  摘要：

  DOI：

  10.1007/bf02253223
• 作为产物：
  描述：

  4-乙基间苯二酚 、 alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 三氟化硼 作用下， 以 吡啶 、 乙醚 为溶剂， 反应 12.0h， 生成 7-hydroxy-2-trifluoromethyl-3-(1-methyl-2-benzimidazolyl)-6-ethylchromone
  参考文献：
  名称：

  异黄酮异类似物的化学。20.异黄酮的苯并咪唑类似物

  摘要：

  DOI：

  10.1007/bf02253223

文献信息

• [EN] METHODS AND USE OF BIFUNCTIONAL ENZYME-BUILDING CLAMP-SHAPED MOLECULES<br/>[FR] PROCÉDÉS ET UTILISATION DE MOLÉCULES EN FORME DE PINCE GÉNÉRANT UNE ENZYME BIFONCTIONNELLE
  申请人：UNIV PENNSYLVANIA

  公开号：WO2012125913A1

  公开（公告）日：2012-09-20

  This invention is in the fields of cancer therapy. More particularly it concerns compounds which are useful agents for inhibiting cell proliferative disorders, especially those disorders characterized by over activity and/or inappropriate activity of a EGFR, including EGFR-related cancers, and methods for treating these disorders.

  这项发明涉及癌症治疗领域。更具体地，它涉及一些化合物，这些化合物是用于抑制细胞增殖异常的有效药物，特别是那些由EGFR过度活跃和/或不适当活跃引起的疾病，包括EGFR相关的癌症，并提供了治疗这些疾病的方法。
• Transcription factor modulating compounds and methods of use thereof
  申请人：Levy Stuart B.

  公开号：US20090131401A1

  公开（公告）日：2009-05-21

  Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

  本发明提供了可用作抗感染剂的取代苯并咪唑化合物，其可降低微生物的耐药性、毒力或生长。本发明还提供了制备和使用取代苯并咪唑化合物的方法，以及其制备的药物制剂，例如用于减少抗生素耐药性和抑制生物膜的制剂。
• MUTATION MIMICKING COMPOUNDS THAT BIND TO THE KINASE DOMAIN OF EGFR
  申请人：Berezov Alan

  公开号：US20140135298A1

  公开（公告）日：2014-05-15

  This invention is in the fields of cancer therapy. More particularly it concerns compounds which are useful agents for treating cell proliferative disorders, especially those disorders characterized by over activity and/or inappropriate activity of a EGFR, including EGFR-related cancers, particularly for expanding the efficacy of drugs previously developed for this purpose, and for methods of treatments using the compounds for this purpose.

  这项发明涉及癌症治疗领域。更具体地说，它涉及化合物，这些化合物是用于治疗细胞增殖性疾病的有用药剂，特别是那些以EGFR的过度活动和/或不适当活动为特征的疾病，包括EGFR相关癌症，特别是为了扩大先前为此目的开发的药物的功效，并使用这些化合物进行治疗的方法。
• METHODS AND USE OF BIFUNCTIONAL ENZYME-BUILDING CLAMP-SHAPED MOLECULES
  申请人：The Trustees of The University of Pennsylvania

  公开号：EP2685980B1

  公开（公告）日：2017-12-06
• Novel therapeutic target for protozoal diseases
  申请人：Rathore Dharmender

  公开号：US20070148185A1

  公开（公告）日：2007-06-28

  A novel Hemozoin Detoxification Protein (HDP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. HDP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, HDP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on HDP, or antigenic epitopes of HDP, either alone or in combination with other parasite antigens. Methods for the development and use of compounds that inhibit the catalytic activity of HDP, and diagnostic and laboratory methods utilizing HDP are also provided. HDP is also referred to herein as Fasciclin Related Adhesive Protein (FRAP).