3-[3,4-Dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-2,6-dioxo-4-pyrimidinecarboxylic acid

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 3-[3,4-Dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-2,6-dioxo-4-pyrimidinecarboxylic acid
• 英文别名: 3-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,6-dioxopyrimidine-4-carboxylic acid
• 化学式: C₁₀H₁₂N₂O₈
• 分子量: 288.21
• InChiKey: FKCRAVPPBFWEJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  157
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside
  申请人：——

  公开号：US20020193314A1

  公开（公告）日：2002-12-19

  A desired isomer is selectively prepared by phosphorolyzing and isomerizing an anomer mixture of a 1-phosphorylated saccharide derivative while crystallizing one of the isomers to displace the equilibrium. Furthermore, using the action of a nucleoside phosphorylase, a nucleoside is prepared from the 1-phosphorylated saccharide derivative obtained and a base with improved stereoselectivity and a higher yield. This process is an anomer-selective process for preparing a 1-phosphorylated saccharide derivative and a nucleoside.

  通过磷酸解和异构化1-磷酸化糖衍生物的环式异构体混合物，有选择性地制备所需的异构体，同时通过结晶其中一种异构体以移动平衡。此外，利用核苷酸磷酸化酶的作用，从获得的1-磷酸化糖衍生物和一种改善立体选择性和更高产率的碱基中制备核苷酸。该过程是用于制备1-磷酸化糖衍生物和核苷酸的环式选择性过程。
• Compositions and Methods for the Inhibition of Methyltransferases
  申请人：Northeastern University

  公开号：US20150057243A1

  公开（公告）日：2015-02-26

  Methods and compositions disclosed herein relate to detecting, analyzing, isolating and inhibiting methyltransferases, methyltransferase substrates, S-adenosyl-methionine-binding proteins and RNA, including for the treatment of disease.

  本文披露的方法和组合与检测、分析、分离和抑制甲基转移酶、甲基转移酶底物、S-腺苷甲硫氨酸结合蛋白和RNA有关，包括用于治疗疾病。
• [EN] LACTONE INTERMEDIATES OF NICOTINAMIDE RIBOSIDE AND NICOTINATE RIBOSIDE<br/>[FR] INTERMÉDIAIRES DE LACTONE DE NICOTINAMIDE RIBOSIDE ET DE NICOTINATE RIBOSIDE
  申请人：UNIV BELFAST

  公开号：WO2018033639A1

  公开（公告）日：2018-02-22

  The present invention is directed to lactones of the following structural formula for use as precursors of NAD, and their use as nutritional supplements.

  本发明涉及以下结构式的内酯，用作NAD的前体，并且它们的用途作为营养补充剂。
• [EN] GLYCYRRHIZIN OR DERIVATIVES THEREOF FOR TREATING OR PREVENTING SEVERE ACUTE RESPIRATORY SYNDROME (SARS)<br/>[FR] PROCEDES DE TRAITEMENT ET DE PREVENTION DU SYNDROME RESPIRATOIRE AIGU SEVERE (SRAS)
  申请人：JOHANN WOLFGANG GOETHE UNIVERS

  公开号：WO2004108122A1

  公开（公告）日：2004-12-16

  The invention provides methods for preventing, treating, managing or ameliorating viral infections, in particular, Severe Acute Respiratory Syndrome (SARS). More specifically, the invention provides methods for preventing, treating, managing or ameliorating a SARS-associated coronavirus or one or more symptoms thereof by administering Glycyrrhizin and/or derivatives thereof The invention also provides methods for preventing, treating, managing or ameliorating a SARS-associated coronavirus or one or more symptoms thereof by administering Glycyrrhizin and/or a derivative thereof in combination with a prophylactic or therapeutic agent other than Glycyrrhizin or a derivative thereof.

  本发明提供了预防、治疗、管理或改善病毒感染，特别是严重急性呼吸综合症（SARS）的方法。更具体地，本发明提供了通过给予甘草甜素及/或其衍生物来预防、治疗、管理或改善SARS相关冠状病毒或其一个或多个症状的方法。本发明还提供了通过给予甘草甜素及/或其衍生物与除甘草甜素或其衍生物之外的预防性或治疗性药剂的组合来预防、治疗、管理或改善SARS相关冠状病毒或其一个或多个症状的方法。
• [EN] PRODUCTION OF NMN AND ITS DERIVATIVES VIA MICROBIAL PROCESSES<br/>[FR] PRODUCTION DE NMN ET DE SES DÉRIVÉS PAR DES PROCÉDÉS MICROBIENS
  申请人：CONAGEN INC

  公开号：WO2021226044A1

  公开（公告）日：2021-11-11

  The present invention relates to microbial production of nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), and nicotinamide adenine dinucleotide (NAD) using a genetically modified bacterium.

  本发明涉及利用基因改造的细菌进行尼克酰胺单核苷酸（NMN）、尼克酰胺核苷酸（NR）和尼克酰胺腺嘌呤二核苷酸（NAD）的微生物生产。