2-Amino-3-[hydroxy-(3-octadecanoyloxy-2-tetradecanoyloxypropoxy)phosphoryl]oxypropanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 2-Amino-3-[hydroxy-(3-octadecanoyloxy-2-tetradecanoyloxypropoxy)phosphoryl]oxypropanoic acid
• 英文别名: 2-amino-3-[hydroxy-(3-octadecanoyloxy-2-tetradecanoyloxypropoxy)phosphoryl]oxypropanoic acid
• 化学式: C₃₈H₇₄NO₁₀P
• 分子量: 736.0
• InChiKey: FMJXBRZFHKZLFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  50
• 可旋转键数：
  40
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  172
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• Immunotherapeutic Nanoparticles And Methods Relating Thereto
  申请人：Wake Forest University Health Sciences

  公开号：US20220193108A1

  公开（公告）日：2022-06-23

  Compositions containing lipid nanoparticles and nucleic acid therapeutic agents are disclosed. For example, calcium phosphate nanoparticles having a lipid coating are provided, wherein the calcium phosphate nanoparticles include a cyclic dinucleotide and the lipid coating includes phosphatidylserine. The compositions can be formulated for administration to the lungs of a subject via inhalation, or for administration via injection. Methods for the treatment of lung cancer and other cancers are also described. Targeted delivery of therapeutic agents such as cyclic dinucleotides to antigen presenting immune cells via the disclosed methods can elicit beneficial antitumor immunity.
• [EN] IMMUNOTHERAPEUTIC NANOPARTICLES AND METHODS RELATING THERETO<br/>[FR] NANOPARTICULES IMMUNOTHÉRAPEUTIQUES ET PROCÉDÉS ASSOCIÉS
  申请人：UNIV WAKE FOREST HEALTH SCIENCES

  公开号：WO2020210317A1

  公开（公告）日：2020-10-15

  Compositions containing lipid nanoparticles and nucleic acid therapeutic agents are disclosed. For example, calcium phosphate nanoparticles having a lipid coating are provided, wherein the calcium phosphate nanoparticles include a cyclic dinucleotide and the lipid coating includes phosphatidylserine. The compositions can be formulated for administration to the lungs of a subject via inhalation, or for administration via injection. Methods for the treatment of lung cancer and other cancers are also described. Targeted delivery of therapeutic agents such as cyclic dinucleotides to antigen presenting immune cells via the disclosed methods can elicit beneficial antitumor immunity.