Isosorbide-derived epoxies and methods of making same are disclosed. Isosorbide and its isomers are attached to glycidyl ether to make crosslinkable epoxy resin monomers. Adding the hydrophobic functional group into the backbone of isosorbide epoxy or adjusting the amount and type of crosslinker is operable to modify the mechanical properties and water uptake ratio (from <1 wt % to >50 wt %) of the isosorbide-derived epoxies for different uses. High water uptake epoxies with controllable biodegradation rate are suitable for drug delivery systems or extracellular matrices for biomedical applications, while low water uptake epoxies with strong mechanical properties may be used for can coatings, bone cements and other industrial additives and adhesives.
本文公开了
异山梨醇衍生的环氧
树脂和制备方法。将
异山梨醇及其同分异构体与环氧
丙烷醚连接以制备交联型环氧
树脂单体。将疏
水性功能基添加到
异山梨醇环氧
树脂的主链中或调整
交联剂的数量和类型可操作地修改
异山梨醇衍生的环氧
树脂的机械性能和吸
水比率(从<1wt%到>50wt%)以适应不同的用途。具有可控
生物降解率的高吸
水性环氧
树脂适用于药物传递系统或
生物医学应用的细胞外基质,而具有强机械性能的低吸
水性环氧
树脂可用于罐涂料、骨
水泥和其他工业添加剂和粘合剂。