3-hydroxy-4-(4-dihydroxyphenyl)-2-butanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-hydroxy-4-(4-dihydroxyphenyl)-2-butanone
• 英文别名: 3-hydroxy-4-(4-hydroxyphenyl)-2-butanone；3-hydroxy-4-(4-hydrophenyl)-2-butanone；HHPB；3-Hydroxy-4-(4-hydroxyphenyl)butan-2-one
• 化学式: C₁₀H₁₂O₃
• 分子量: 180.203
• InChiKey: GAIOEEDYZHKHNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-hydroxy-4-(4-dihydroxyphenyl)-2-butanone 、 乙醛 、 2-苯乙胺 以 水 为溶剂， 生成 dermazolium A
  参考文献：
  名称：

  阴道细菌 Dermabacter vaginalis 的抗菌咪唑代谢物 dermazolium A 的分离、结构解析、全合成和生物合成

  摘要：

  Dermabacter vaginalis是一种人源性细菌，于 2016 年从一名韩国女性的阴道液中分离出来。虽然已经报道了Dermabacter属中的几种人类相关物种，但对其生物活性代谢物的研究很少。Dermazolium A ( 1 ) 是一种罕见的咪唑代谢物，与五种已知代谢物 ( 2–6 ) 一起从D. vaginalis中分离出来，它们的化学结构通过 NMR、HRMS 和 MS/MS 数据分析确定。使用预测的前体和1的仿生全合成的喂养实验证实了其结构，并提出了1的生物合成途径。对分离化合物的抗菌试验表明1是一种温和的抗菌剂，对耐甲氧西林金黄色葡萄球菌(MRSA) USA300、副干酪乳杆菌亚种的 MIC 值为 41 µg/mL 。副干酪KCTC 3510 和表皮短杆菌KCTC 3090。

  DOI：

  10.1007/s12272-022-01424-z

文献信息

• Compositions and Methods for Fermentation of Biomass
  申请人：Parekh Sarad

  公开号：US20100268000A1

  公开（公告）日：2010-10-21

  In one aspect, this invention relates to production of useful fermentation end-products from biomass through simultaneous hydrolysis and fermentation by a microorganism, such as Clostridium phytofermentans . The invention also relates to the development of a process for efficient pretreatment and conversion of lignocellulosic biomass to end-products with high conversion efficiency (yield). In another aspect, methods for producing a fermentation end-product by fermenting hexose (C6) and pentose (C5) sugars with a microorganism, such as Clostridium phytofermentans are disclosed herein.

  在一个方面，这项发明涉及通过微生物（如植物发酵槽菌）的同时水解和发酵，从生物质中生产有用的发酵终产物。该发明还涉及开发一种高效预处理和转化木质纤维素生物质为高转化效率（产率）的终产物的过程。在另一个方面，本文介绍了利用微生物（如植物发酵槽菌）发酵己糖（C6）和戊糖（C5）糖产生发酵终产物的方法。
• BIOFUEL PRODUCTION
  申请人：Yoshikuni Yasuo

  公开号：US20090139134A1

  公开（公告）日：2009-06-04

  Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity chemical enriched, refinery-produced petroleum products are also provided, as well as methods for producing the same.

  提供了用于将多糖转化为适当的单糖或寡糖的方法、酶、重组微生物和微生物系统，例如从生物质中提取的多糖。同时提供了将适当的单糖或寡糖转化为商品化学品，如生物燃料的方法。本文描述的方法生产的商品化学品也提供了。此外，还提供了商品化学品富集的、精炼生产的石油产品，以及生产这些产品的方法。
• Processes for making pioglitazone and compounds of the processes
  申请人：Zhu Jie

  公开号：US20070167629A1

  公开（公告）日：2007-07-19

  Pioglitazone can be made via a Darzens Condensation reaction in an industrially useful process.

  Pioglitazone可以通过Darzens缩合反应在工业上进行制备。
• METHODS AND COMPOSITIONS FOR PRODUCING CHEMICAL PRODUCTS FROM C. PHYTOFERMENTANS
  申请人：Schmalisch Matthias

  公开号：US20110183382A1

  公开（公告）日：2011-07-28

  This invention provides systems and methods for the production of compounds by C. phytofermentans. C. phytofermentans is genetically-engineered for hydrolysis and fermentation of carbonaceous biomass to synthesize compounds of commercial value.

  这项发明提供了通过C. phytofermentans生产化合物的系统和方法。C. phytofermentans被基因工程化，用于水解和发酵碳质生物质以合成具有商业价值的化合物。
• Isolated alcohol dehydrogenase enzymes and uses thereof
  申请人：Bio Architecture Lab, Inc.

  公开号：EP2463374A2

  公开（公告）日：2012-06-13

  Bacterial polynucleotides and polypeptides are provided in which the polypeptides have a dehydrogenase activity, such as an alcohol dehydrogenase (ADH) activity, an uronate, a 4-deoxy-L-erythro-5-hexoseulose uronate (DEHU) ((4S,5S)-4,5 dihydroxy-2,6-dioxohexanoate) hydrogenase activity, a 2-keto-3-deoxy-D-gluconate dehydrogenase activity, a D-mannuronate hydrogenase activity, and/or a D-mannnonate dehydrogenase activity. Methods, enzymes, recombinant microorganism, and microbial systems are also provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided.

  提供了细菌多核苷酸和多肽，其中的多肽具有脱氢酶活性，如醇脱氢酶（ADH）活性、尿酸盐、4-脱氧-L-赤式-5-己糖尿酸盐（DEHU）（（4S、5S）-4,5-二羟基-2,6-二氧代己酸）氢化酶活性、2-酮基-3-脱氧-D-葡萄糖酸脱氢酶活性、D-甘露酸氢化酶活性和/或 D-甘露酸脱氢酶活性。还提供了将多糖（如来自生物质的多糖）转化为合适的单糖或低聚糖，以及将合适的单糖或低聚糖转化为商品化学品（如生物燃料）的方法、酶、重组微生物和微生物系统。还提供了通过本文所述方法生产的商品化学品。